GENR { RETE|ID 1 HUgn0000001 CHR 1 19 DID 1 LocusLink:1 MAP 1 19q13.4 NAM 1 alpha-1-B glycoprotein ORG 1 Homo sapiens SYM 1 A1BG ID|HUgn0000001 DID|LocusLink:1 ORG|Homo sapiens RSQ|REFSEQ:NM_130786 RPA|REFPROT:NP_570602 DBA|XM:NM_130786 |NA:AC010642 |NA:AF414429 |NA:AK055885 |NA:AK056201 |NA:BC035719 |NA:none PAC|XP:NP_570602 SYM|A1BG NAM|alpha-1-B glycoprotein SYN|A1B |ABG |GAB FNC|alpha 1B-glycoprotein |biological_process unknown ; GO:0000004 REAB|The protein encoded by this gene is a plasma glycoprotein of unknown function. The |protein shows sequence similarity to the variable regions of some immunoglobulin |supergene family member proteins. CHR|19 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=390608 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=1[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:119638 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_130786 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_130786 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=390608 DBL|UNIGENE:Hs.390608 |OMIM:138670 |SNP:1 MAP|19q13.4 ENZ|molecular_function unknown ; GO:0005554 CEL|extracellular ; GO:0005576 HG|species == rat; score == 409; expect == 2e-114; MEOW:ref|NP_071594.2| (44%) |species == rat; score == 354; expect == 1.2e-97; MEOW:ref|XP_235351.2| (46%) |species == Human; gene == IGSF1; score == 184; expect == 1.3e-46; MEOW:HUgn0003547 (31%) |species == Mouse; gene == Igsf1; score == 174; expect == 1.3e-43; MEOW:MGgn0032854 (30%) } # EOR GENR { RETE|ID 1 HUgn0000002 CHR 1 12 DID 1 LocusLink:2 MAP 1 12p13.3-p12.3 NAM 1 alpha-2-macroglobulin ORG 1 Homo sapiens SYM 1 A2M ID|HUgn0000002 DID|LocusLink:2 ORG|Homo sapiens RSQ|REFSEQ:NM_000014 RPA|REFPROT:NP_000005 DBA|XM:NM_000014 |NA:X68728 |NA:Z11711 |NA:BC040071 |NA:M11313 |NA:M36501 |NA:none PAC|XP:NP_000005 SYM|A2M NAM|alpha-2-macroglobulin FNC|alpha 2 macroglobulin precursor |intracellular protein transport ; GO:0006886 REAB|Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits |many proteases, including trypsin, thrombin and collagenase. A2M is implicated in |Alzheimer disease (AD) due to its ability to mediate the clearance and degradation |of A-beta, the major component of beta-amyloid deposits. CHR|12 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=74561 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=2[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:119639 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_000014 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_000014 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=74561 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=05010 DBL|UNIGENE:Hs.74561 |OMIM:103950 |SNP:2 |UWCM:119639.html MAP|12p13.3-p12.3 PHP|Alzheimer disease, susceptibility to |Emphysema due to alpha-2-macroglobulin deficiency ENZ|protein carrier activity ; GO:0008320 |serine protease inhibitor activity ; GO:0004867 |wide-spectrum protease inhibitor activity ; GO:0017114 HG|species == rat; score == 2118; expect == 0.0; MEOW:ref|NP_036620.1| (73%) |species == Human; gene == PZP; score == 2069; expect == 0.0; MEOW:HUgn0005858 (72%) |species == Mouse; gene == A2m; score == 2065; expect == 0.0; MEOW:MGgn0041598 (71%) |species == rat; score == 1713; expect == 0.0; MEOW:ref|XP_346725.1| (59%) |species == Mouse; gene == Mug1; score == 1697; expect == 0.0; MEOW:MGgn0008069 (58%) |species == Fruitfly; gene == TepII; score == 480; expect == 3e-135; MEOW:FBgn0041182 (28%) |species == Worm; gene == ZK337.1b; score == 462; expect == 8e-130; MEOW:CEgn0020894 (28%) |species == Worm; gene == ZK337.1c; score == 457; expect == 3e-128; MEOW:CEgn0034425 (27%) |species == Worm; gene == ZK337.1a; score == 456; expect == 2e-128; MEOW:CEgn0020893 (28%) |species == Mosquito; gene == LOC19522; score == 342; expect == 4.0e-94; MEOW:AGgn0019522 (33%) } # EOR GENR { RETE|ID 1 HUgn0000003 CHR 1 12 DID 1 LocusLink:3 MAP 1 12p13.3-p12.3 NAM 1 alpha-2-macroglobulin pseudogene ORG 1 Homo sapiens SYM 1 A2MP ID|HUgn0000003 DID|LocusLink:3 CLA|Pseudogene ORG|Homo sapiens DBA|NA:M24415 SYM|A2MP NAM|alpha-2-macroglobulin pseudogene CHR|12 MAP|12p13.3-p12.3 DBL|SNP:3 URL|http://www.gdb.org/gdb-bin/genera/accno?GDB:128103 } # EOR GENR { RETE|ID 1 HUgn0000008 CHR 1 11 DID 1 LocusLink:8 MAP 1 11p15 NAM 1 atrophia areata, peripapillary chorioretinal degeneration ORG 1 Homo sapiens SYM 1 AA ID|HUgn0000008 DID|LocusLink:8 ORG|Homo sapiens SYM|AA NAM|atrophia areata, peripapillary chorioretinal degeneration CHR|11 DBL|OMIM:108985 MAP|11p15 PHP|Atrophia areata URL|http://www.gdb.org/gdb-bin/genera/accno?GDB:568984 } # EOR GENR { RETE|ID 1 HUgn0000009 CHR 1 8 DID 1 LocusLink:9 MAP 1 8p23.1-p21.3 NAM 1 N-acetyltransferase 1 (arylamine N-acetyltransferase) ORG 1 Homo sapiens SYM 1 NAT1 ID|HUgn0000009 DID|LocusLink:9 ORG|Homo sapiens RSQ|REFSEQ:NM_000662 RPA|REFPROT:NP_000653 DBA|XM:NM_000662 |NA:AF008204 |NA:AF032677 |NA:AF032678 |NA:AF067408 |NA:AF071552 |NA:AF082903 |NA:AF082904 |NA:U80835 |NA:X17059 |NA:BC013732 |NA:BC047666 |NA:BX647521 |NA:D90041 PAC|XP:NP_000653 SYM|NAT1 NAM|N-acetyltransferase 1 (arylamine N-acetyltransferase) SYN|AAC1 FNC|N-acetyltransferase 1 CHR|8 PRD|arylamine N-acetyltransferase-1 |arylamide acetylase 1 (N-acetyltransferase 1) URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=155956 |http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=458430 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=9[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:125364 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_000662 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_000662 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=155956 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=458430 |http://www.pharmgkb.org/do/serve?objCls=Gene&objId=PA17 |http://www.louisville.edu/medschool/pharmacology/NAT.html DBL|UNIGENE:Hs.155956 |UNIGENE:Hs.458430 |OMIM:108345 |SNP:9 ENZ|EC:2.3.1.5 |arylamine N-acetyltransferase activity ; GO:0004060 MAP|8p23.1-p21.3 PHP|Arylamine N-acetyltransferase 1; N- or O-acetylates arylamines and heterocyclic amines, detoxifies carcinogens and xenobiotics HG|species == Mouse; gene == Nat2; score == 510; expect == 3e-145; MEOW:MGgn0008196 (81%) |species == rat; score == 501; expect == 1e-142; MEOW:ref|NP_446306.1| (80%) |species == Human; gene == NAT2; score == 483; expect == 7e-137; MEOW:HUgn0000010 (80%) |species == rat; score == 461; expect == 2e-130; MEOW:ref|NP_446305.1| (75%) |species == Mouse; gene == Nat1; score == 454; expect == 1e-128; MEOW:MGgn0008195 (73%) |species == rat; score == 417; expect == 3e-117; MEOW:ref|XP_224762.1| (68%) |species == Mouse; gene == Nat3; score == 410; expect == 4e-115; MEOW:MGgn0008197 (68%) } # EOR GENR { RETE|ID 1 HUgn0000010 CHR 1 8 DID 1 LocusLink:10 MAP 1 8p22 NAM 1 N-acetyltransferase 2 (arylamine N-acetyltransferase) ORG 1 Homo sapiens SYM 1 NAT2 ID|HUgn0000010 DID|LocusLink:10 ORG|Homo sapiens RSQ|REFSEQ:NM_000015 RPA|REFPROT:NP_000006 DBA|XM:NM_000015 |NA:AF042740 |NA:AF055874 |NA:AF055875 |NA:D10870 |NA:D10871 |NA:D10872 |NA:M75163 |NA:M75164 |NA:U23052 |NA:U23434 |NA:U53473 |NA:X14672 |NA:BC015878 |NA:D90040 |NA:D90042 |NA:none PAC|XP:NP_000006 SYM|NAT2 NAM|N-acetyltransferase 2 (arylamine N-acetyltransferase) SYN|AAC2 FNC|arylamide acetylase 2 |metabolism ; GO:0008152 REAB|The intronless NAT2 gene encodes N-acetyltransferase 2 (arylamine N-acetyltransferase |2). This enzyme functions to both activate and deactivate arylamine and hydrazine |drugs and carcinogens. Polymorphisms in this gene are reponsible for the N-acetylation |polymorphism in which human populations segregate into rapid,intermediate, and slow |acetylator phenotypes. Polymorphisms in NAT2 are also associated with higher incidences |of cancer and drug toxicity.A second arylamine N-acetyltransferase gene (NAT1) is |located near NAT2. CHR|8 PRD|Arylamine N-acetyltransferase-2 |arylamide acetylase 2 (N-acetyltransferase 2, isoniazid inactivation) URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=2 |http://www.gdb.org/gdb-bin/genera/accno?GDB:125365 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_000015 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_000015 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=2 |http://www.pharmgkb.org/do/serve?objCls=Gene&objId=PA18 |http://www.louisville.edu/medschool/pharmacology/NAT.html DBL|UNIGENE:Hs.2 |OMIM:243400 |SNP:10 ENZ|EC:2.3.1.5 |arylamine N-acetyltransferase activity ; GO:0004060 |acetyltransferase activity ; GO:0016407 |transferase activity ; GO:0016740 MAP|8p22 HG|species == Human; gene == NAT1; score == 483; expect == 7e-137; MEOW:HUgn0000009 (80%) |species == Mouse; gene == Nat2; score == 458; expect == 2e-129; MEOW:MGgn0008196 (74%) |species == rat; score == 450; expect == 5e-127; MEOW:ref|NP_446306.1| (73%) |species == rat; score == 443; expect == 4e-125; MEOW:ref|NP_446305.1| (74%) |species == Mouse; gene == Nat1; score == 433; expect == 5e-122; MEOW:MGgn0008195 (72%) |species == rat; score == 390; expect == 4e-109; MEOW:ref|XP_224762.1| (66%) |species == Mouse; gene == Nat3; score == 382; expect == 2e-106; MEOW:MGgn0008197 (65%) } # EOR GENR { RETE|ID 1 HUgn0000011 DID 1 LocusLink:11 NAM 1 arylamide acetylase pseudogene ORG 1 Homo sapiens SYM 1 AACP ID|HUgn0000011 DID|LocusLink:11 CLA|Pseudogene ORG|Homo sapiens SYM|AACP NAM|arylamide acetylase pseudogene SYN|NATP URL|http://www.gdb.org/gdb-bin/genera/accno?GDB:132838 } # EOR GENR { RETE|ID 1 HUgn0000012 CHR 1 14 DID 1 LocusLink:12 MAP 1 14q32.1 NAM 1 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 ORG 1 Homo sapiens SYM 1 SERPINA3 ID|HUgn0000012 DID|LocusLink:12 ORG|Homo sapiens RSQ|REFSEQ:NM_001085 RPA|REFPROT:NP_001076 DBA|XM:NM_001085 |NA:X00947 |NA:X68733 |NA:AF089747 |NA:AK093049 |NA:AK123091 |NA:BC003559 |NA:BC010530 |NA:BC013189 |NA:BC034554 |NA:J05176 |NA:K01500 |NA:M18906 |NA:none PAC|XP:NP_001076 SYM|SERPINA3 NAM|serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 SYN|ACT |AACT FNC|alpha-1-antichymotrypsin, precursor |acute-phase response ; GO:0006953 REAB|The protein encoded by this gene is a plasma protease inhibitor and member of the |serine protease inhibitor class. Polymorphisms in this protein appear to be tissue |specific and influence protease targeting. Variation in this protein's sequence |have been implicated in Alzheimer's disease, and deficiency of this protein has |been associated with liver disease. Mutations have been identified in patients |with Parkinson disease and chronic obstructive pulmonary disease. CHR|14 PRD|antichymotrypsin |alpha-1-antichymotrypsin DBL|OMIM:107280 |SNP:12 MAP|14q32.1 PHP|Alpha-1-antichymotrypsin deficiency |Cerebrovascular disease, occlusive URL|http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=12[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:118955 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_001085 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001085 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=05010 ENZ|serine protease inhibitor activity ; GO:0004867 HG|species == Mouse; gene == Serpina3c; score == 437; expect == 5e-123; MEOW:MGgn0006809 (54%) |species == Mouse; gene == Serpina3n; score == 435; expect == 2e-122; MEOW:MGgn0011168 (57%) |species == rat; score == 410; expect == 7e-115; MEOW:ref|NP_113719.1| (56%) |species == Mouse; gene == Serpina3m; score == 409; expect == 1e-114; MEOW:MGgn0011169 (56%) |species == rat; score == 399; expect == 2e-111; MEOW:ref|XP_216782.2| (52%) |species == rat; score == 390; expect == 1e-108; MEOW:ref|NP_036789.1| (53%) |species == Mouse; gene == Serpina3k; score == 380; expect == 5e-106; MEOW:MGgn0011166 (53%) |species == rat; score == 367; expect == 6e-102; MEOW:ref|XP_234496.2| (57%) |species == rat; score == 332; expect == 2.5e-91; MEOW:ref|XP_234494.2| (45%) |species == Human; gene == SERPINA6; score == 296; expect == 1.8e-80; MEOW:HUgn0000866 (44%) |species == Human; gene == SERPINA7; score == 281; expect == 6.2e-76; MEOW:HUgn0006906 (41%) |species == Human; gene == SERPINA1; score == 280; expect == 1.1e-75; MEOW:HUgn0005265 (39%) |species == Human; gene == SERPINA5; score == 278; expect == 3.9e-75; MEOW:HUgn0005104 (45%) |species == Human; gene == SERPINA4; score == 275; expect == 3.6e-74; MEOW:HUgn0005267 (43%) |species == Human; gene == LOC256394; score == 261; expect == 4.6e-70; MEOW:HUgn0256394 (37%) |species == Human; gene == SERPINA11; score == 248; expect == 5.0e-66; MEOW:HUgn0327657 (41%) |species == Mosquito; score == 148; expect == 2.8e-36; MEOW:AGgn0015833 (31%) |species == Mosquito; gene == LOC23182; score == 140; expect == 1.0e-33; MEOW:AGgn0023182 (30%) |species == Fruitfly; gene == Spn1; score == 139; expect == 2.4e-33; MEOW:FBgn0028988 (31%) |species == Mosquito; gene == LOC22846; score == 136; expect == 1.9e-32; MEOW:AGgn0022846 (30%) |species == Mosquito; gene == LOC23448; score == 136; expect == 1.1e-32; MEOW:AGgn0023448 (30%) |species == Fruitfly; gene == Spn43Aa; score == 133; expect == 1.3e-31; MEOW:FBgn0024294 (30%) |species == Fruitfly; gene == Spn2; score == 133; expect == 9.9e-32; MEOW:FBgn0028987 (32%) |species == Worm; gene == srp-6; score == 131; expect == 4.4e-31; MEOW:CEgn0003919 (27%) } # EOR GENR { RETE|ID 1 HUgn0000013 CHR 1 3 DID 1 LocusLink:13 MAP 1 3q21.3-q25.2 NAM 1 arylacetamide deacetylase (esterase) ORG 1 Homo sapiens SYM 1 AADAC ID|HUgn0000013 DID|LocusLink:13 ORG|Homo sapiens RSQ|REFSEQ:NM_001086 RPA|REFPROT:NP_001077 DBA|XM:NM_001086 |NA:BC020706 |NA:BC032309 |NA:L32179 |NA:none PAC|XP:NP_001077 SYM|AADAC NAM|arylacetamide deacetylase (esterase) SYN|DAC FNC|arylacetamide deacetylase |metabolism ; GO:0008152 REAB|Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine |N-acetyltransferase, which catalyzes one of the initial biotransformation pathways |for arylamine and heterocyclic amine carcinogens CHR|3 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=444003 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=13[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:392587 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_001086 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001086 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=444003 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00650 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00623 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00040 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00563 DBL|UNIGENE:Hs.444003 |OMIM:600338 |SNP:13 ENZ|EC:3.1.1.- |hydrolase activity ; GO:0016787 MAP|3q21.3-q25.2 CEL|microsome ; GO:0005792 |integral to membrane ; GO:0016021 HG|species == Mouse; gene == Aadac; score == 575; expect == 1e-164; MEOW:MGgn0025424 (69%) |species == rat; score == 558; expect == 2e-159; MEOW:ref|NP_065413.1| (66%) |species == Human; gene == LOC344752; score == 406; expect == 1e-113; MEOW:HUgn0344752 (50%) } # EOR GENR { RETE|ID 1 HUgn0000014 CHR 1 2 DID 1 LocusLink:14 MAP 1 2q35 NAM 1 angio-associated, migratory cell protein ORG 1 Homo sapiens SYM 1 AAMP ID|HUgn0000014 DID|LocusLink:14 ORG|Homo sapiens RSQ|REFSEQ:NM_001087 RPA|REFPROT:NP_001078 DBA|XM:NM_001087 |NA:AK131047 |NA:BC008809 |NA:BC014122 |NA:BC020244 |NA:BC039866 |NA:M95627 |NA:none PAC|XP:NP_001078 SYM|AAMP NAM|angio-associated, migratory cell protein FNC|angio-associated, migratory cell protein |cell motility ; GO:0006928 REAB|The gene product is an immunoglobulin-type protein. It is found to be expressed strongly |in endothelial cells, cytotrophoblasts, and poorly differentiated colon adenocarcinoma |cells found in lymphatics. The protein contains a heparin-binding domain and mediates |heparin-sensitive cell adhesion. CHR|2 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=83347 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=14[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:4573993 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_001087 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001087 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=83347 DBL|UNIGENE:Hs.83347 |OMIM:603488 |SNP:14 MAP|2q35 ENZ|heparin binding ; GO:0008201 HG|species == rat; score == 778; expect == 0.0; MEOW:ref|XP_217441.2| (97%) |species == Mouse; gene == Aamp; score == 700; expect == 0.0; MEOW:MGgn0000008 (98%) |species == Mosquito; gene == LOC13761; score == 253; expect == 1.1e-67; MEOW:AGgn0013761 (40%) |species == Mosquito; score == 252; expect == 1.9e-67; MEOW:AGgn0011371 (40%) |species == Weed; gene == At1g71840; score == 222; expect == 3.3e-58; MEOW:ATgn0004027 (33%) |species == rice; score == 217; expect == 7.0e-57; MEOW:gnl|TIGR|8360.m04289 (31%) |species == Fruitfly; gene == CG5114; score == 188; expect == 7.3e-48; MEOW:FBgn0036460 (31%) } # EOR GENR { RETE|ID 1 HUgn0000015 CHR 1 17 DID 1 LocusLink:15 MAP 1 17q25 NAM 1 arylalkylamine N-acetyltransferase ORG 1 Homo sapiens SYM 1 AANAT ID|HUgn0000015 DID|LocusLink:15 ORG|Homo sapiens RSQ|REFSEQ:NM_001088 RPA|REFPROT:NP_001079 DBA|XM:NM_001088 |NA:U40391 |NA:U40347 |NA:none PAC|XP:NP_001079 SYM|AANAT NAM|arylalkylamine N-acetyltransferase SYN|SNAT |AA-NAT FNC|arylalkylamine N-acetyltransferase |circadian rhythm ; GO:0007623 REAB|Arylalkylamine N-acetyltransferase belongs to the superfamily of acetyltransferases. |It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm |in melatonin production in the vertebrate pineal gland. Melatonin is essential for |seasonal reproduction, modulates the function of the circadian clock in the suprachiasmatic |nucleus, and influences activity and sleep. This enzyme is rapidly inactivated when |animals are exposed to light at night. This protein is 80% identical to sheep and |rat AA-NAT. Arylalkylamine N-acetyltransferase may contribute a multifactorial genetic |diseases such as altered behavior in sleep/wake cycle. CHR|17 PRD|Serotonin N-acetyltransferase |serotonin N-acetyltransferase URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=431417 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=15[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:700076 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_001088 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001088 |http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=PureSearch&db=books&details_term=arev.section.500+OR+arev.section.520+OR+arev.section.524 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00380 |http://www.pharmgkb.org/do/serve?objCls=Gene&objId=PA24366 DBL|UNIGENE:Hs.431417 |OMIM:600950 |SNP:15 ENZ|EC:2.3.1.87 |acyltransferase activity ; GO:0008415 |aralkylamine N-acetyltransferase activity ; GO:0004059 |transferase activity ; GO:0016740 MAP|17q25 HG|species == rat; score == 357; expect == 2.4e-99; MEOW:ref|NP_036950.1| (84%) |species == Mouse; gene == Aanat; score == 356; expect == 2.8e-99; MEOW:MGgn0000009 (86%) |species == Zfish; gene == aanat2; score == 238; expect == 1.3e-64; MEOW:ZFgn0000609 (60%) } # EOR GENR { RETE|ID 1 HUgn0000016 CHR 1 16 DID 1 LocusLink:16 MAP 1 16q22 NAM 1 alanyl-tRNA synthetase ORG 1 Homo sapiens SYM 1 AARS ID|HUgn0000016 DID|LocusLink:16 ORG|Homo sapiens RSQ|REFSEQ:NM_001605 RPA|REFPROT:NP_001596 DBA|XM:NM_001605 |NA:BC011451 |NA:D16969 |NA:D32050 |NA:none PAC|XP:NP_001596 SYM|AARS NAM|alanyl-tRNA synthetase FNC|alanyl-tRNA synthetase |alanyl-tRNA aminoacylation ; GO:0006419 |tRNA processing ; GO:0008033 |protein biosynthesis ; GO:0006412 REAB|The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of |the class II enzymes. Class II tRNA synthases evolved early in evolution and are |highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide |human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the |enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs |that contain the cognate trinucleotide anticodons. They consist of a catalytic |domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and |a second domain which interacts with the rest of the tRNA structure. CHR|16 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=315137 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=16[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:595485 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_001605 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001605 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=315137 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00970 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00252 DBL|UNIGENE:Hs.315137 |OMIM:601065 |SNP:16 ENZ|EC:6.1.1.7 |tRNA binding ; GO:0000049 |nucleic acid binding ; GO:0003676 |ATP binding ; GO:0005524 |alanine-tRNA ligase activity ; GO:0004813 |ligase activity ; GO:0016874 MAP|16q22 CEL|soluble fraction ; GO:0005625 |cytoplasm ; GO:0005737 HG|species == rat; score == 1807; expect == 0.0; MEOW:ref|XP_214690.2| (93%) |species == Mosquito; gene == LOC13174; score == 1140; expect == 0.0; MEOW:AGgn0013174 (59%) |species == Worm; gene == ars-2; score == 1102; expect == 0.0; MEOW:CEgn0009587 (57%) |species == Yeast; gene == ALA1; score == 896; expect == 0.0; MEOW:SGgn0005862 (50%) |species == Weed; gene == At1g50200; score == 850; expect == 0.0; MEOW:ATgn0001757 (48%) |species == Human; gene == AARSL; score == 786; expect == 0.0; MEOW:HUgn0057505 (45%) |species == Mouse; gene == Aars; score == 656; expect == 0.0; MEOW:MGgn0042046 (96%) |species == ecoli; score == 541; expect == 1e-154; MEOW:ref|NP_417177.1| (38%) |species == Fruitfly; gene == Aats-ala-m; score == 489; expect == 4e-138; MEOW:FBgn0028962 (34%) |species == Fruitfly; gene == Aats-ala; score == 474; expect == 6e-134; MEOW:FBgn0027094 (48%) |species == rice; score == 459; expect == 1e-128; MEOW:gnl|TIGR|8354.m01280 (33%) |species == rice; score == 438; expect == 1e-122; MEOW:gnl|TIGR|8362.m00744 (62%) |species == rice; score == 406; expect == 1e-112; MEOW:gnl|TIGR|8362.m00745 (39%) } # EOR GENR { RETE|ID 1 HUgn0000017 CHR 1 19 DID 1 LocusLink:17 MAP 1 19q13 NAM 1 adeno-associated virus integration site 1 ORG 1 Homo sapiens SYM 1 AAVS1 ID|HUgn0000017 DID|LocusLink:17 ORG|Homo sapiens DBA|NA:S51329 SYM|AAVS1 NAM|adeno-associated virus integration site 1 SYN|AAV CHR|19 DBL|OMIM:102699 MAP|19q13 URL|http://www.gdb.org/gdb-bin/genera/accno?GDB:125369 } # EOR GENR { RETE|ID 1 HUgn0000018 CHR 1 16 DID 1 LocusLink:18 MAP 1 16p13.3 NAM 1 4-aminobutyrate aminotransferase ORG 1 Homo sapiens SYM 1 ABAT ID|HUgn0000018 DID|LocusLink:18 ORG|Homo sapiens RSQ|REFSEQ:NM_000663 RPA|REFPROT:NP_000654 DBA|XM:NM_000663 |NA:BC013965 |NA:BC015628 |NA:BC031413 |NA:L32961 |NA:S75578 |NA:U80226 |NA:none PAC|XP:NP_000654 SYM|ABAT NAM|4-aminobutyrate aminotransferase SYN|GABAT FNC|4-aminobutyrate aminotransferase precursor |synaptic transmission ; GO:0007268 |neurotransmitter catabolism ; GO:0042135 |aminobutyrate metabolism ; GO:0009448 REAB|4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric |acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous |system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits |complexed to pyridoxal-5-phosphate. ABAT cDNA encodes a 500-amino acid protein that |is over 95% similar to the pig protein. GABA is estimated to be present in nearly |one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant |alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency |phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, |refractory seizures, and EEG abnormalities. CHR|16 PRD|GABA transferase URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=1588 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=18[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:581658 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_000663 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_000663 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=1588 |http://tango01.cit.nih.gov/mitodat/search.taf?_function=list&locusid=18 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00650 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00251 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00640 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00410 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00252 DBL|UNIGENE:Hs.1588 |OMIM:137150 |SNP:18 ENZ|EC:2.6.1.19 |4-aminobutyrate transaminase activity ; GO:0003867 |transferase activity ; GO:0016740 MAP|16p13.3 PHP|GABA-transaminase deficiency CEL|mitochondrial matrix ; GO:0005759 HG|species == rat; score == 936; expect == 0.0; MEOW:ref|NP_112265.1| (90%) |species == Mouse; gene == 9630038C02Rik; score == 756; expect == 0.0; MEOW:MGgn0041356 (77%) |species == Mosquito; gene == LOC21720; score == 528; expect == 2e-150; MEOW:AGgn0021720 (54%) |species == Fruitfly; gene == CG7433; score == 516; expect == 8e-147; MEOW:FBgn0036927 (53%) |species == Yeast; gene == UGA1; score == 367; expect == 2e-102; MEOW:SGgn0003251 (42%) } # EOR GENR { RETE|ID 1 HUgn0000019 CHR 1 9 DID 1 LocusLink:19 MAP 1 9q31.1 NAM 1 ATP-binding cassette, sub-family A (ABC1), member 1 ORG 1 Homo sapiens SYM 1 ABCA1 ID|HUgn0000019 DID|LocusLink:19 ORG|Homo sapiens RSQ|REFSEQ:NM_005502 RPA|REFPROT:NP_005493 DBA|XM:NM_005502 |NA:AF165286 |NA:AF275948 |NA:AB055982 |NA:AF165281 |NA:AF285167 |NA:AJ012376 |NA:AK024328 |NA:none PAC|XP:NP_005493 SYM|ABCA1 NAM|ATP-binding cassette, sub-family A (ABC1), member 1 SYN|TGD |ABC1 |CERP |HDLDT1 FNC|ATP-binding cassette, sub-family A member 1 |phagocytosis, engulfment ; GO:0006911 |cholesterol metabolism ; GO:0008203 |small molecule transport ; GO:0006832 REAB|The membrane-associated protein encoded by this gene is a member of the superfamily |of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules |across extra- and intracellular membranes. ABC genes are divided into seven distinct |subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member |of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC |subfamily found exclusively in multicellular eukaryotes. With cholesterol as its |substrate, this protein functions as a cholesteral efflux pump in the cellular lipid |removal pathway. Mutations in this gene have been associated with Tangier's disease |and familial high-density lipoprotein deficiency. CHR|9 PRD|ATP-binding cassette 1 |cholesterol efflux regulatory protein |high density lipoprotein deficiency, Tangier type, 1 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=147259 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=19[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:305294 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_005502 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_005502 |http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=PureSearch&db=books&details_term=mono_001.section.144+OR+mono_001.section.166+OR+mono_001.table.145+OR+mono_001.table.153+OR+mono_001.table.155 |http://www.ncbi.nlm.nih.gov/disease/tangier.html |http://www.humanabc.org DBL|UNIGENE:Hs.147259 |OMIM:600046 |SNP:19 MAP|9q31.1 PHP|Cerebral amyloid angiopathy |HDL deficiency, familial |Tangier disease ENZ|anion transporter activity ; GO:0008509 |sterol transporter activity ; GO:0015248 |ATP-binding cassette (ABC) transporter activity ; GO:0004009 |adenosinetriphosphatase activity ; GO:0004002 CEL|integral to plasma membrane ; GO:0005887 |membrane fraction ; GO:0005624 HG|species == Mouse; gene == Abca1; score == 4052; expect == 0.0; MEOW:MGgn0000015 (95%) |species == Human; gene == ABCA4; score == 2128; expect == 0.0; MEOW:HUgn0000024 (50%) |species == Human; gene == ABCA7; score == 1932; expect == 0.0; MEOW:HUgn0010347 (52%) |species == rat; score == 1900; expect == 0.0; MEOW:ref|XP_232954.2| (91%) |species == Mosquito; score == 491; expect == 2e-138; MEOW:AGgn0028715 (37%) |species == Mosquito; gene == LOC22300; score == 489; expect == 5e-138; MEOW:AGgn0022300 (34%) |species == Mosquito; gene == LOC9155; score == 485; expect == 8e-137; MEOW:AGgn0009155 (36%) |species == Fruitfly; gene == CG1718; score == 461; expect == 1e-129; MEOW:FBgn0031170 (35%) |species == Mosquito; score == 459; expect == 6e-129; MEOW:AGgn0027182 (36%) |species == Mosquito; gene == LOC13004; score == 429; expect == 5e-120; MEOW:AGgn0013004 (39%) |species == Mosquito; gene == LOC9427; score == 427; expect == 2e-119; MEOW:AGgn0009427 (35%) |species == Fruitfly; gene == CG6052; score == 399; expect == 1e-110; MEOW:FBgn0036747 (32%) |species == Weed; gene == At2g41700; score == 350; expect == 4.2e-96; MEOW:ATgn0007560 (32%) |species == Worm; gene == ced-7; score == 280; expect == 3.6e-75; MEOW:CEgn0000158 (30%) |species == rice; score == 231; expect == 1.2e-60; MEOW:gnl|TIGR|8351.m01020 (29%) |species == rice; score == 229; expect == 5.8e-60; MEOW:gnl|TIGR|8356.m02939 (27%) |species == rice; score == 217; expect == 2.2e-56; MEOW:gnl|TIGR|8354.m03592 (34%) |species == rice; score == 215; expect == 7.7e-56; MEOW:gnl|TIGR|8357.m01639 (28%) |species == rice; score == 213; expect == 4.1e-55; MEOW:gnl|TIGR|8356.m02942 (29%) |species == rice; score == 186; expect == 4.4e-47; MEOW:gnl|TIGR|8356.m02943 (32%) } # EOR GENR { RETE|ID 1 HUgn0000020 CHR 1 9 DID 1 LocusLink:20 MAP 1 9q34 NAM 1 ATP-binding cassette, sub-family A (ABC1), member 2 ORG 1 Homo sapiens SYM 1 ABCA2 ID|HUgn0000020 DID|LocusLink:20 ORG|Homo sapiens RSQ|REFSEQ:NM_001606 RPA|REFPROT:NP_001597 DBA|XM:NM_001606 |NA:AF327658 |NA:AF327659 |NA:AF327660 |NA:AF327661 |NA:AF327662 |NA:AF327663 |NA:AF327664 |NA:AF327665 |NA:AF327666 |NA:AF327667 |NA:AF327668 |NA:AF327669 |NA:AF327670 |NA:AF327671 |NA:AF327672 |NA:AF327673 |NA:AF327674 |NA:AF327675 |NA:AF327676 |NA:AF327677 |NA:AF327678 |NA:AF327679 |NA:AF327680 |NA:AF327681 |NA:AF327682 |NA:AF327683 |NA:AF327684 |NA:AF327685 |NA:AF327686 |NA:AF327687 |NA:AF327688 |NA:AF327689 |NA:AF327690 |NA:AF327691 |NA:AF327692 |NA:AF327693 |NA:AF327694 |NA:AF327695 |NA:AF327696 |NA:AF327697 |NA:AF327698 |NA:AF327699 |NA:AF327700 |NA:AF327701 |NA:AF327702 |NA:AF327703 |NA:AF327704 |NA:AF327705 |NA:AB028985 |NA:AF178941 |NA:AF327657 |NA:AL162060 |NA:BC008755 |NA:BC029282 |NA:U18235 |NA:U18236 |NA:none PAC|XP:NP_001597 SYM|ABCA2 NAM|ATP-binding cassette, sub-family A (ABC1), member 2 SYN|ABC2 |KIAA1062 FNC|ATP-binding cassette, sub-family A, member 2 |small molecule transport ; GO:0006832 REAB|The membrane-associated protein encoded by this gene is a member of the superfamily |of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules |across extra- and intracellular membranes. ABC genes are divided into seven distinct |subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member |of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC |subfamily found exclusively in multicellular eukaryotes. This protein is highly |expressed in brain tissue and may play a role in macrophage lipid metabolism and |neural development. CHR|9 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=421202 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=20[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:305295 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_001606 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001606 |http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=PureSearch&db=books&details_term=mono_001.section.144+OR+mono_001.section.166+OR+mono_001.table.145+OR+mono_001.table.155 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=421202 |http://zearth.kazusa.or.jp/huge/gfpage/KIAA1062 |http://www.humanabc.org DBL|UNIGENE:Hs.421202 |OMIM:600047 |SNP:20 MAP|9q34 ENZ|ATP binding ; GO:0005524 |ATP-binding cassette (ABC) transporter activity ; GO:0004009 |transporter activity ; GO:0005215 CEL|integral to membrane ; GO:0016021 |membrane fraction ; GO:0005624 HG|species == rat; score == 4232; expect == 0.0; MEOW:ref|NP_077372.1| (92%) |species == Mouse; gene == Abca2; score == 4089; expect == 0.0; MEOW:MGgn0000017 (90%) |species == Human; gene == ABCA1; score == 1494; expect == 0.0; MEOW:HUgn0000019 (44%) |species == Mosquito; score == 491; expect == 2e-138; MEOW:AGgn0027182 (39%) |species == Mosquito; gene == LOC22300; score == 488; expect == 9e-138; MEOW:AGgn0022300 (38%) |species == Mosquito; score == 474; expect == 2e-133; MEOW:AGgn0028715 (38%) |species == Mosquito; gene == LOC9155; score == 470; expect == 3e-132; MEOW:AGgn0009155 (36%) |species == Mosquito; gene == LOC9427; score == 468; expect == 8e-132; MEOW:AGgn0009427 (36%) |species == Fruitfly; gene == CG1718; score == 463; expect == 3e-130; MEOW:FBgn0031170 (33%) |species == Mosquito; gene == LOC13004; score == 431; expect == 1e-120; MEOW:AGgn0013004 (38%) |species == Fruitfly; gene == CG6052; score == 406; expect == 6e-113; MEOW:FBgn0036747 (33%) |species == Weed; gene == At2g41700; score == 374; expect == 4e-103; MEOW:ATgn0007560 (35%) |species == Worm; gene == ced-7; score == 327; expect == 2.8e-89; MEOW:CEgn0000158 (32%) |species == rice; score == 227; expect == 2.2e-59; MEOW:gnl|TIGR|8351.m01020 (27%) |species == rice; score == 226; expect == 6.1e-59; MEOW:gnl|TIGR|8356.m02942 (29%) |species == rice; score == 225; expect == 6.4e-58; MEOW:gnl|TIGR|8357.m01639 (27%) |species == rice; score == 221; expect == 9.2e-57; MEOW:gnl|TIGR|8354.m03592 (28%) |species == rice; score == 219; expect == 2.7e-56; MEOW:gnl|TIGR|8356.m02939 (26%) |species == rice; score == 203; expect == 2.0e-51; MEOW:gnl|TIGR|8356.m02943 (26%) } # EOR GENR { RETE|ID 1 HUgn0000021 CHR 1 16 DID 1 LocusLink:21 MAP 1 16p13.3 NAM 1 ATP-binding cassette, sub-family A (ABC1), member 3 ORG 1 Homo sapiens SYM 1 ABCA3 ID|HUgn0000021 DID|LocusLink:21 ORG|Homo sapiens RSQ|REFSEQ:NM_001089 RPA|REFPROT:NP_001080 DBA|XM:NM_001089 |NA:AC005212 |NA:AC007162 |NA:AB070929 |NA:U78735 |NA:X97187 |NA:none PAC|XP:NP_001080 SYM|ABCA3 NAM|ATP-binding cassette, sub-family A (ABC1), member 3 SYN|ABC3 |ABC-C |LBM180 |EST111653 FNC|ATP-binding cassette, sub-family A member 3 |drug resistance ; GO:0009315 |transport ; GO:0006810 REAB|The membrane-associated protein encoded by this gene is a member of the superfamily |of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules |across extra- and intracellular membranes. ABC genes are divided into seven distinct |subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member |of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC |subfamily found exclusively in multicellular eukaryotes. The full transporter encoded |by this gene may be involved in development of resistance to xenobiotics and engulfment |during programmed cell death. CHR|16 PRD|ABC transporter 3 |ATP-binding cassette 3 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=26630 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=21[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:3770735 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_001089 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001089 |http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=PureSearch&db=books&details_term=mono_001.section.144+OR+mono_001.section.166+OR+mono_001.table.145+OR+mono_001.table.155 |http://www.humanabc.org DBL|UNIGENE:Hs.26630 |OMIM:601615 |SNP:21 MAP|16p13.3 ENZ|nucleotide binding ; GO:0000166 |ATP binding ; GO:0005524 |ATP-binding cassette (ABC) transporter activity ; GO:0004009 |transporter activity ; GO:0005215 CEL|integral to membrane ; GO:0016021 |membrane fraction ; GO:0005624 HG|species == Mouse; gene == Abca3; score == 2888; expect == 0.0; MEOW:MGgn0013319 (87%) |species == rat; score == 2851; expect == 0.0; MEOW:ref|XP_220219.2| (85%) |species == Mosquito; gene == LOC9155; score == 1125; expect == 0.0; MEOW:AGgn0009155 (38%) |species == Mosquito; score == 1101; expect == 0.0; MEOW:AGgn0028715 (37%) |species == Mosquito; gene == LOC22300; score == 1087; expect == 0.0; MEOW:AGgn0022300 (37%) |species == Fruitfly; gene == CG1718; score == 1062; expect == 0.0; MEOW:FBgn0031170 (37%) |species == Mosquito; score == 1048; expect == 0.0; MEOW:AGgn0027182 (36%) |species == Mosquito; gene == LOC9427; score == 1005; expect == 0.0; MEOW:AGgn0009427 (36%) |species == Fruitfly; gene == CG6052; score == 865; expect == 0.0; MEOW:FBgn0036747 (32%) |species == Weed; gene == At2g41700; score == 682; expect == 0.0; MEOW:ATgn0007560 (31%) |species == Worm; gene == ced-7; score == 535; expect == 7e-152; MEOW:CEgn0000158 (26%) |species == Human; gene == ABCA2; score == 511; expect == 3e-144; MEOW:HUgn0000020 (38%) |species == Human; gene == ABCA1; score == 503; expect == 3e-142; MEOW:HUgn0000019 (39%) |species == Human; gene == ABCA4; score == 490; expect == 3e-138; MEOW:HUgn0000024 (38%) |species == Human; gene == ABCA7; score == 462; expect == 7e-130; MEOW:HUgn0010347 (36%) |species == Human; gene == ABCA12; score == 456; expect == 7e-128; MEOW:HUgn0026154 (33%) |species == rice; score == 251; expect == 1.1e-66; MEOW:gnl|TIGR|8351.m01020 (30%) |species == rice; score == 240; expect == 4.3e-63; MEOW:gnl|TIGR|8356.m02939 (29%) |species == rice; score == 235; expect == 3.3e-61; MEOW:gnl|TIGR|8354.m03592 (31%) |species == rice; score == 233; expect == 3.6e-61; MEOW:gnl|TIGR|8357.m01639 (29%) |species == rice; score == 231; expect == 8.0e-60; MEOW:gnl|TIGR|8356.m02942 (30%) |species == rice; score == 217; expect == 1.2e-55; MEOW:gnl|TIGR|8356.m02943 (30%) |species == ecoli; score == 136; expect == 1.0e-32; MEOW:ref|NP_414669.1| (36%) |species == ecoli; score == 132; expect == 1.5e-31; MEOW:ref|NP_415315.1| (34%) |species == ecoli; score == 132; expect == 1.5e-31; MEOW:ref|NP_417943.1| (36%) } # EOR GENR { RETE|ID 1 HUgn0000022 CHR 1 X DID 1 LocusLink:22 MAP 1 Xq12-q13 NAM 1 ATP-binding cassette, sub-family B (MDR/TAP), member 7 ORG 1 Homo sapiens SYM 1 ABCB7 ID|HUgn0000022 DID|LocusLink:22 ORG|Homo sapiens RSQ|REFSEQ:NM_004299 RPA|REFPROT:NP_004290 DBA|XM:NM_004299 |NA:AB005289 |NA:AF038950 |NA:AF078777 |NA:AF133659 |NA:AK001418 |NA:BC006323 |NA:BT009918 |NA:BX537833 |NA:none PAC|XP:NP_004290 SYM|ABCB7 NAM|ATP-binding cassette, sub-family B (MDR/TAP), member 7 SYN|ABC7 |ASAT |Atm1p |EST140535 FNC|ATP-binding cassette, sub-family B, member 7 |transport ; GO:0006810 REAB|The membrane-associated protein encoded by this gene is a member of the superfamily |of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules |across extra- and intra-cellular membranes. ABC genes are divided into seven distinct |subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member |of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug |resistance as well as antigen presentation. This gene encodes a half-transporter |involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur |cluster precursors as its substrates, this protein may play a role in metal homeostasis. | Mutations in this gene have been implicated in X-linked sideroblastic anemia with |ataxia. CHR|X PRD|ATP-binding cassette 7 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=370480 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=22[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:7016795 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_004299 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_004299 |http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=PureSearch&db=books&details_term=mono_001.section.144+OR+mono_001.section.152+OR+mono_001.section.179+OR+mono_001.table.145+OR+mono_001.table.153+OR+mono_001.table.155 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=370480 |http://www.geneclinics.org/query?mim=300135 |http://www.pharmgkb.org/do/serve?objCls=Gene&objId=PA24389 |http://www.humanabc.org DBL|UNIGENE:Hs.370480 |OMIM:300135 |SNP:22 MAP|Xq12-q13 PHP|Anemia, sideroblastic, with ataxia ENZ|heme transporter activity ; GO:0015232 |nucleotide binding ; GO:0000166 |ATP binding ; GO:0005524 |ATP-binding cassette (ABC) transporter activity ; GO:0004009 CEL|mitochondrion ; GO:0005739 |integral to membrane ; GO:0016021 |mitochondrial inner membrane ; GO:0005743 HG|species == rat; score == 1237; expect == 0.0; MEOW:ref|XP_217569.2| (88%) |species == Mosquito; gene == LOC13018; score == 676; expect == 0.0; MEOW:AGgn0013018 (59%) |species == Fruitfly; gene == CG7955; score == 656; expect == 0.0; MEOW:FBgn0035244 (58%) |species == Worm; gene == Y74C10AM.1; score == 622; expect == 2e-178; MEOW:CEgn0028856 (56%) |species == Weed; gene == At5g58270; score == 597; expect == 1e-170; MEOW:ATgn0024285 (54%) |species == Weed; gene == At4g28630; score == 581; expect == 5e-166; MEOW:ATgn0019383 (52%) |species == Weed; gene == At4g28620; score == 574; expect == 5e-164; MEOW:ATgn0019382 (50%) |species == Yeast; gene == ATM1; score == 552; expect == 3e-157; MEOW:SGgn0004916 (48%) |species == rice; score == 498; expect == 1e-140; MEOW:gnl|TIGR|8354.m00272 (57%) |species == Mouse; gene == Abcb6; score == 437; expect == 2e-122; MEOW:MGgn0016464 (41%) |species == Human; gene == ABCB6; score == 433; expect == 2e-121; MEOW:HUgn0010058 (41%) |species == ecoli; score == 232; expect == 7.7e-62; MEOW:ref|NP_415434.1| (32%) |species == Zfish; gene == abcc4; score == 156; expect == 3.1e-39; MEOW:ZFgn0013883 (29%) } # EOR GENR { RETE|ID 1 HUgn0000023 CHR 1 6 DID 1 LocusLink:23 MAP 1 6p21.33 NAM 1 ATP-binding cassette, sub-family F (GCN20), member 1 ORG 1 Homo sapiens SYM 1 ABCF1 ID|HUgn0000023 DID|LocusLink:23 ORG|Homo sapiens RSQ|REFSEQ:NM_001090 RPA|REFPROT:NP_001081 DBA|XM:NM_001090 |NA:AB023052 |NA:AC006138 |NA:AF027302 |NA:AL832430 |NA:BC016772 |NA:BC034488 PAC|XP:NP_001081 SYM|ABCF1 NAM|ATP-binding cassette, sub-family F (GCN20), member 1 SYN|ABC27 |ABC50 |EST123147 FNC|ATP-binding cassette, sub-family F, member 1 |protein biosynthesis ; GO:0006412 |inflammatory response ; GO:0006954 REAB|The protein encoded by this gene is a member of the superfamily of ATP-binding cassette |(ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular |membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, |MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. |Unlike other members of the superfamily, this protein lacks the transmembrane domains |which are characteristic of most ABC transporters. This protein may be regulated |by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis |and the inflammation process. CHR|6 PRD|ATP-binding cassette 50 |ATP-binding cassette 50 (TNF-alpha stimulated) URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=9573 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=23[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:9836817 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_001090 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001090 |http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=PureSearch&db=books&details_term=mono_001.section.144+OR+mono_001.section.211+OR+mono_001.table.145+OR+mono_001.table.155 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=9573 |http://www.humanabc.org DBL|UNIGENE:Hs.9573 |OMIM:603429 |SNP:23 MAP|6p21.33 ENZ|translation factor activity, nucleic acid binding ; GO:0008135 |ATP binding ; GO:0005524 |ATP-binding cassette (ABC) transporter activity ; GO:0004009 HG|species == chimp; score == 1038; expect == 0.0; MEOW:sp|BAC78179|BAC78179 (99%) |species == rat; score == 995; expect == 0.0; MEOW:ref|XP_342084.1| (86%) |species == Mosquito; gene == LOC16545; score == 700; expect == 0.0; MEOW:AGgn0016545 (66%) |species == Worm; gene == F18E2.2; score == 654; expect == 0.0; MEOW:CEgn0008740 (61%) |species == Mosquito; score == 624; expect == 5e-179; MEOW:AGgn0025805 (64%) |species == Weed; gene == At3g54540; score == 495; expect == 3e-140; MEOW:ATgn0028529 (43%) |species == Fruitfly; gene == CG1703; score == 493; expect == 1e-139; MEOW:FBgn0030321 (67%) |species == rice; score == 444; expect == 6e-125; MEOW:gnl|TIGR|8360.m02979 (49%) |species == Fruitfly; gene == CG9330; score == 440; expect == 1e-123; MEOW:FBgn0036888 (46%) |species == Weed; gene == At1g64550; score == 424; expect == 1e-118; MEOW:ATgn0003295 (39%) |species == rice; score == 408; expect == 5e-114; MEOW:gnl|TIGR|8356.m04386 (42%) |species == Weed; gene == At5g60790; score == 407; expect == 1e-113; MEOW:ATgn0021021 (42%) |species == rice; score == 407; expect == 7e-114; MEOW:gnl|TIGR|8357.m03355 (43%) |species == Yeast; gene == YER036C; score == 394; expect == 1e-109; MEOW:SGgn0000838 (39%) |species == Mouse; gene == Abcf3; score == 393; expect == 2e-109; MEOW:MGgn0013333 (42%) |species == Human; gene == ABCF3; score == 373; expect == 2e-103; MEOW:HUgn0055324 (42%) |species == rice; score == 370; expect == 2e-102; MEOW:gnl|TIGR|8352.m05260 (41%) |species == Human; gene == ABCF2; score == 367; expect == 1e-101; MEOW:HUgn0010061 (38%) |species == Yeast; gene == GCN20; score == 355; expect == 4.0e-98; MEOW:SGgn0001905 (36%) |species == Mouse; gene == Abcf2; score == 354; expect == 9.5e-98; MEOW:MGgn0013332 (37%) |species == ecoli; score == 312; expect == 5.5e-85; MEOW:ref|NP_417811.1| (36%) |species == ecoli; score == 259; expect == 3.4e-69; MEOW:ref|NP_415341.1| (31%) } # EOR GENR { RETE|ID 1 HUgn0000024 CHR 1 1 DID 1 LocusLink:24 MAP 1 1p22.1-p21 NAM 1 ATP-binding cassette, sub-family A (ABC1), member 4 ORG 1 Homo sapiens SYM 1 ABCA4 ID|HUgn0000024 DID|LocusLink:24 ORG|Homo sapiens RSQ|REFSEQ:NM_000350 RPA|REFPROT:NP_000341 DBA|XM:NM_000350 |NA:Y15635 |NA:AF000148 |NA:AF001945 |NA:U88667 |NA:none PAC|XP:NP_000341 SYM|ABCA4 NAM|ATP-binding cassette, sub-family A (ABC1), member 4 SYN|FFM |RMP |ABCR |RP19 |STGD |ABC10 |STGD1 FNC|ATP-binding cassette, sub-family A member 4 |phototransduction, visible light ; GO:0007603 |transport ; GO:0006810 |vision ; GO:0007601 REAB|The membrane-associated protein encoded by this gene is a member of the superfamily |of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules |across extra- and intracellular membranes. ABC genes are divided into seven distinct |subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member |of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC |subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific |ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively |in retina photoreceptor cells, indicating the gene product mediates transport of |an essental molecule across the photoreceptor cell membrane. Mutations in this gene |are found in patients diagnosed with Stargardt disease and are associated with retinitis |pigmentosa-19 and macular degeneration age-related 2. CHR|1 PRD|rim protein |ATP binding cassette transporter |ATP-binding transporter, retina-specific URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=416707 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=24[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:370748 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_000350 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_000350 |http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=PureSearch&db=books&details_term=mono_001.section.144+OR+mono_001.section.161+OR+mono_001.section.166+OR+mono_001.table.145+OR+mono_001.table.153+OR+mono_001.table.155 |http://www.geneclinics.org/query?mim=601691 |http://www.humanabc.org |http://www.retina-international.com/sci-news/abcrmut.htm DBL|UNIGENE:Hs.416707 |OMIM:601691 |SNP:24 |UWCM:370748.html MAP|1p22.1-p21 PHP|Cone-rod dystrophy 3 |Fundus flavimaculatus |Macular dystrophy, age-related, 2 |Retinitis pigmentosa-19 |Stargardt disease-1 ENZ|nucleotide binding ; GO:0000166 |ATP binding ; GO:0005524 |ATP-binding cassette (ABC) transporter activity ; GO:0004009 |transporter activity ; GO:0005215 CEL|integral to plasma membrane ; GO:0005887 |membrane fraction ; GO:0005624 HG|species == Mouse; gene == Abca4; score == 4012; expect == 0.0; MEOW:MGgn0000016 (88%) |species == rat; score == 2481; expect == 0.0; MEOW:ref|XP_241525.2| (80%) |species == Human; gene == ABCA1; score == 2128; expect == 0.0; MEOW:HUgn0000019 (50%) |species == Mosquito; score == 472; expect == 7e-133; MEOW:AGgn0028715 (35%) |species == Mosquito; gene == LOC9155; score == 467; expect == 2e-131; MEOW:AGgn0009155 (34%) |species == Mosquito; score == 431; expect == 2e-120; MEOW:AGgn0027182 (33%) |species == Fruitfly; gene == CG1718; score == 422; expect == 5e-118; MEOW:FBgn0031170 (37%) |species == Mosquito; gene == LOC22300; score == 418; expect == 1e-116; MEOW:AGgn0022300 (37%) |species == Mosquito; gene == LOC9427; score == 414; expect == 2e-115; MEOW:AGgn0009427 (31%) |species == Mosquito; gene == LOC13004; score == 403; expect == 3e-112; MEOW:AGgn0013004 (38%) |species == Fruitfly; gene == CG6052; score == 368; expect == 2e-101; MEOW:FBgn0036747 (31%) |species == Weed; gene == At2g41700; score == 340; expect == 4.5e-93; MEOW:ATgn0007560 (36%) |species == Worm; gene == ced-7; score == 295; expect == 1.1e-79; MEOW:CEgn0000158 (30%) |species == rice; score == 228; expect == 9.2e-59; MEOW:gnl|TIGR|8356.m02942 (32%) |species == rice; score == 220; expect == 1.9e-56; MEOW:gnl|TIGR|8357.m01639 (28%) |species == rice; score == 208; expect == 1.0e-53; MEOW:gnl|TIGR|8351.m01020 (34%) |species == rice; score == 202; expect == 4.1e-51; MEOW:gnl|TIGR|8354.m03592 (35%) |species == rice; score == 197; expect == 1.7e-49; MEOW:gnl|TIGR|8356.m02943 (36%) |species == rice; score == 188; expect == 8.0e-47; MEOW:gnl|TIGR|8356.m02939 (35%) |species == ecoli; score == 133; expect == 3.2e-31; MEOW:ref|NP_415315.1| (37%) } # EOR GENR { RETE|ID 1 HUgn0000025 CHR 1 9 DID 1 LocusLink:25 MAP 1 9q34.1 NAM 1 v-abl Abelson murine leukemia viral oncogene homolog 1 ORG 1 Homo sapiens SYM 1 ABL1 ID|HUgn0000025 DID|LocusLink:25 ORG|Homo sapiens RSQ|REFSEQ:NM_005157 |REFSEQ:NM_007313 RPA|REFPROT:NP_005148 |REFPROT:NP_009297 DBA|XM:NM_005157 |XM:NM_007313 |NA:K00009 |NA:M13099 |NA:U07563 |NA:M14752 |NA:M14753 |NA:M30833 |NA:X16416 |NA:none PAC|XP:NP_005148 |XP:NP_009297 SYM|ABL1 NAM|v-abl Abelson murine leukemia viral oncogene homolog 1 SYN|ABL |JTK7 |p150 |c-ABL |v-abl FNC|v-abl Abelson murine leukemia viral oncogene homolog 1 isoform a |v-abl Abelson murine leukemia viral oncogene homolog 1 isoform b |S-specific transcription in mitotic cell cycle ; GO:0000115 |DNA damage response, signal transduction resulting in induction of apoptosis ; GO:0008630 |mismatch repair ; GO:0006298 |cell growth and/or maintenance ; GO:0008151 |protein amino acid phosphorylation ; GO:0006468 |regulation of transcription, DNA-dependent ; GO:0006355 |intracellular signaling cascade ; GO:0007242 |regulation of cell cycle ; GO:0000074 REAB|The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase |that has been implicated in processes of cell differentiation, cell division, cell |adhesion, and stress response. Activity of c-Abl protein is negatively regulated |by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. |The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) |and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding |activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated |phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed |as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced |to the common exons 2-11. CHR|9 PRD|proto-oncogene tyrosine-protein kinase ABL1 |Abelson murine leukemia viral (v-abl) oncogene homolog 1 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=446504 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=25[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:119640 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_005157 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_005157 |http://www.ncbi.nlm.nih.gov/disease/cml.html |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=04110 |http://www.pharmgkb.org/do/serve?objCls=Gene&objId=PA24413 DBL|UNIGENE:Hs.446504 |OMIM:189980 |SNP:25 ENZ|EC:2.7.1.112 |protein-tyrosine kinase activity ; GO:0004713 |ATP binding ; GO:0005524 |DNA binding ; GO:0003677 |transferase activity ; GO:0016740 MAP|9q34.1 PHP|Leukemia, Philadelphia chromosome-positive, resistant to imatinib CEL|nucleus ; GO:0005634 HG|species == rat; score == 1534; expect == 0.0; MEOW:ref|XP_231137.2| (76%) |species == rat; score == 1534; expect == 0.0; MEOW:ref|XP_347218.1| (76%) |species == Human; gene == ABL2; score == 932; expect == 0.0; MEOW:HUgn0000027 (66%) |species == Mosquito; gene == LOC2451; score == 739; expect == 0.0; MEOW:AGgn0002451 (70%) |species == Fruitfly; gene == Abl; score == 733; expect == 0.0; MEOW:FBgn0000017 (74%) |species == Worm; gene == abl-1; score == 565; expect == 6e-161; MEOW:CEgn0000002 (55%) |species == Mouse; gene == Frk; score == 380; expect == 1e-105; MEOW:MGgn0004424 (42%) |species == Mouse; gene == Btk; score == 339; expect == 3.3e-93; MEOW:MGgn0000908 (42%) |species == Mouse; gene == Yes; score == 335; expect == 4.4e-92; MEOW:MGgn0013129 (44%) |species == Mouse; gene == Fyn; score == 333; expect == 2.2e-91; MEOW:MGgn0004482 (43%) |species == Mouse; gene == Fgr; score == 332; expect == 3.7e-91; MEOW:MGgn0004295 (42%) |species == Mouse; gene == Lck; score == 324; expect == 1.3e-88; MEOW:MGgn0007008 (42%) |species == Mouse; gene == Hck; score == 322; expect == 5.0e-88; MEOW:MGgn0005314 (42%) |species == Mouse; gene == Src; score == 322; expect == 5.0e-88; MEOW:MGgn0011237 (42%) |species == Mouse; gene == Lyn; score == 317; expect == 2.1e-86; MEOW:MGgn0007294 (41%) |species == Mouse; gene == Blk; score == 315; expect == 8.0e-86; MEOW:MGgn0000816 (43%) |species == Mouse; gene == Csk; score == 306; expect == 2.0e-83; MEOW:MGgn0001705 (39%) |species == Mouse; gene == Tec; score == 306; expect == 2.4e-83; MEOW:MGgn0012151 (37%) |species == Zfish; gene == itk; score == 284; expect == 1.2e-77; MEOW:ZFgn0000238 (37%) |species == chimp; score == 194; expect == 2.5e-49; MEOW:sp|BAC78172|BAC78172 (37%) |species == Weed; gene == At4g35780; score == 179; expect == 2.9e-45; MEOW:ATgn0017130 (35%) |species == Weed; gene == At2g17700; score == 174; expect == 1.1e-43; MEOW:ATgn0028393 (35%) |species == Weed; gene == At4g38470; score == 168; expect == 8.7e-42; MEOW:ATgn0020261 (36%) |species == Weed; gene == At1g62400; score == 161; expect == 5.6e-40; MEOW:ATgn0006564 (33%) |species == Weed; gene == At5g03730; score == 160; expect == 2.7e-39; MEOW:ATgn0024018 (36%) |species == rice; score == 159; expect == 2.5e-38; MEOW:gnl|TIGR|8357.m03093 (35%) |species == rice; score == 158; expect == 8.4e-39; MEOW:gnl|TIGR|8352.m05524 (33%) |species == Weed; gene == At5g11850; score == 155; expect == 9.5e-38; MEOW:ATgn0025217 (35%) |species == Weed; gene == At3g58640; score == 151; expect == 1.2e-36; MEOW:ATgn0012164 (31%) |species == Weed; gene == At2g31010; score == 147; expect == 5.6e-36; MEOW:ATgn0008444 (31%) |species == rice; score == 144; expect == 6.4e-34; MEOW:gnl|TIGR|8355.m02702 (35%) |species == rice; score == 136; expect == 5.1e-32; MEOW:gnl|TIGR|8351.m03037 (38%) |species == rice; score == 136; expect == 1.3e-31; MEOW:gnl|TIGR|8359.m00564 (32%) |species == rice; score == 136; expect == 9.5e-32; MEOW:gnl|TIGR|8360.m03494 (28%) |species == rice; score == 135; expect == 3.9e-31; MEOW:gnl|TIGR|8351.m04858 (33%) |species == rice; score == 134; expect == 6.6e-31; MEOW:gnl|TIGR|8354.m04232 (28%) } # EOR GENR { RETE|ID 1 HUgn0000026 CHR 1 7 DID 1 LocusLink:26 MAP 1 7q34-q36 NAM 1 amiloride binding protein 1 (amine oxidase (copper-containing)) ORG 1 Homo sapiens SYM 1 ABP1 ID|HUgn0000026 DID|LocusLink:26 ORG|Homo sapiens RSQ|REFSEQ:NM_001091 RPA|REFPROT:NP_001082 DBA|XM:NM_001091 |XM:NM_001091 |NA:X78212 |NA:AK092514 |NA:BC014093 |NA:BX648159 |NA:M55602 |NA:U11862 |NA:U11863 |NA:none PAC|XP:NP_001082 |XP:NP_001082 SYM|ABP1 NAM|amiloride binding protein 1 (amine oxidase (copper-containing)) SYN|DAO |AOC1 FNC|amiloride binding protein 1 precursor |metabolism ; GO:0008152 REAB|This gene encodes a membrane glycoprotein that binds amiloride, a diuretic that acts |by closing epithelial sodium ion channels. Experimental evidence indicates, however, |that the formation of an amiloride sensitive, sodium channel requires complex formation |with additional proteins. Although an association was proposed between this gene |and cystic fibrosis, a disorder involving sodium and water imbalance in the lungs, |genetic evidence showed that it was not involved in producing that disorder. CHR|7 PRD|diamine oxidase |Amiloride-binding protein-1 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=437420 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=26[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:127105 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_001091 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001091 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=437420 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00350 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00340 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00380 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00410 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00960 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00360 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00330 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00260 DBL|UNIGENE:Hs.437420 |OMIM:104610 |SNP:26 ENZ|EC:1.4.3.6 |amine oxidase (copper-containing) activity ; GO:0008122 |copper ion binding ; GO:0005507 |heparin binding ; GO:0008201 |drug binding ; GO:0008144 |oxidoreductase activity ; GO:0016491 MAP|7q34-q36 CEL|peroxisome ; GO:0005777 HG|species == rat; score == 1285; expect == 0.0; MEOW:ref|NP_075224.1| (81%) |species == Mouse; gene == Abp1; score == 1266; expect == 0.0; MEOW:MGgn0016961 (80%) |species == Human; gene == AOC3; score == 530; expect == 2e-150; MEOW:HUgn0008639 (39%) |species == Human; gene == AOC2; score == 506; expect == 2e-143; MEOW:HUgn0000314 (40%) |species == ecoli; score == 142; expect == 6.1e-35; MEOW:ref|NP_415904.1| (28%) |species == Weed; gene == At1g31670; score == 141; expect == 1.5e-33; MEOW:ATgn0000598 (27%) |species == Weed; gene == At4g14940; score == 141; expect == 1.7e-33; MEOW:ATgn0019564 (28%) |species == Weed; gene == At1g31710; score == 138; expect == 1.0e-32; MEOW:ATgn0000604 (28%) |species == Weed; gene == At4g12290; score == 137; expect == 2.1e-32; MEOW:ATgn0020358 (28%) |species == Weed; gene == At1g31690; score == 134; expect == 1.2e-31; MEOW:ATgn0000602 (27%) } # EOR GENR { RETE|ID 1 HUgn0000027 CHR 1 1 DID 1 LocusLink:27 MAP 1 1q24-q25 NAM 1 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) ORG 1 Homo sapiens SYM 1 ABL2 ID|HUgn0000027 DID|LocusLink:27 ORG|Homo sapiens RSQ|REFSEQ:NM_005158 |REFSEQ:NM_007314 RPA|REFPROT:NP_005149 |REFPROT:NP_009298 DBA|XM:NM_005158 |XM:NM_007314 |NA:BX538317 |NA:M35296 |NA:none PAC|XP:NP_005149 |XP:NP_009298 SYM|ABL2 NAM|v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) SYN|ARG |ABLL FNC|v-abl Abelson murine leukemia viral oncogene homolog 2 isoform a |v-abl Abelson murine leukemia viral oncogene homolog 2 isoform b |cell growth and/or maintenance ; GO:0008151 |protein amino acid phosphorylation ; GO:0006468 |intracellular signaling cascade ; GO:0007242 REAB|ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from |ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends |amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal |and tumor cells. The ABL2 gene product is expressed as two variants bearing different |amino termini, both approximately 12-kb in length. CHR|1 PRD|Abelson-related gene |Abelson murine leukemia viral (v-abl) oncogene homolog 2 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=159472 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=27[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:119641 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_007314 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_007314 DBL|UNIGENE:Hs.159472 |OMIM:164690 |SNP:27 ENZ|EC:2.7.1.112 |protein-tyrosine kinase activity ; GO:0004713 |ATP binding ; GO:0005524 |transferase activity ; GO:0016740 MAP|1q24-q25 PHP|Leukemia, acute myeloid, with eosinophilia CEL|cytoplasm ; GO:0005737 HG|species == Human; gene == ABL1; score == 932; expect == 0.0; MEOW:HUgn0000025 (66%) |species == rat; score == 812; expect == 0.0; MEOW:ref|XP_231137.2| (45%) |species == rat; score == 812; expect == 0.0; MEOW:ref|XP_347218.1| (45%) |species == Mosquito; gene == LOC2451; score == 714; expect == 0.0; MEOW:AGgn0002451 (67%) |species == Fruitfly; gene == Abl; score == 705; expect == 0.0; MEOW:FBgn0000017 (72%) |species == Worm; gene == abl-1; score == 559; expect == 3e-159; MEOW:CEgn0000002 (59%) |species == Mouse; gene == Fyn; score == 367; expect == 1e-101; MEOW:MGgn0004482 (43%) |species == Mouse; gene == Fgr; score == 361; expect == 5e-100; MEOW:MGgn0004295 (41%) |species == Mouse; gene == Frk; score == 357; expect == 1.4e-98; MEOW:MGgn0004424 (44%) |species == Mouse; gene == Blk; score == 352; expect == 3.6e-97; MEOW:MGgn0000816 (43%) |species == Mouse; gene == Yes; score == 349; expect == 3.0e-96; MEOW:MGgn0013129 (44%) |species == Mouse; gene == Src; score == 337; expect == 1.2e-92; MEOW:MGgn0011237 (42%) |species == Mouse; gene == Btk; score == 334; expect == 1.4e-91; MEOW:MGgn0000908 (42%) |species == Mouse; gene == Lck; score == 333; expect == 2.2e-91; MEOW:MGgn0007008 (43%) |species == Mouse; gene == Hck; score == 332; expect == 3.8e-91; MEOW:MGgn0005314 (44%) |species == Mouse; gene == Lyn; score == 326; expect == 3.5e-89; MEOW:MGgn0007294 (41%) |species == Mouse; gene == Csk; score == 318; expect == 3.0e-87; MEOW:MGgn0001705 (40%) |species == Mouse; gene == Itk; score == 309; expect == 3.5e-84; MEOW:MGgn0006607 (37%) |species == Mouse; gene == Tec; score == 302; expect == 3.5e-82; MEOW:MGgn0012151 (39%) |species == Zfish; gene == itk; score == 288; expect == 8.1e-79; MEOW:ZFgn0000238 (39%) |species == chimp; score == 177; expect == 6.9e-46; MEOW:sp|BAC78172|BAC78172 (38%) |species == Weed; gene == At4g35780; score == 175; expect == 7.0e-44; MEOW:ATgn0017130 (34%) |species == rice; score == 175; expect == 7.5e-44; MEOW:gnl|TIGR|8357.m03093 (36%) |species == Weed; gene == At4g38470; score == 172; expect == 3.5e-43; MEOW:ATgn0020261 (37%) |species == Weed; gene == At5g03730; score == 162; expect == 5.5e-40; MEOW:ATgn0024018 (38%) |species == rice; score == 162; expect == 3.4e-40; MEOW:gnl|TIGR|8352.m05524 (35%) |species == Weed; gene == At1g62400; score == 155; expect == 3.1e-38; MEOW:ATgn0006564 (31%) |species == Weed; gene == At2g17700; score == 154; expect == 2.8e-37; MEOW:ATgn0028393 (34%) |species == rice; score == 151; expect == 1.2e-36; MEOW:gnl|TIGR|8359.m00564 (30%) |species == Weed; gene == At3g58640; score == 149; expect == 4.7e-36; MEOW:ATgn0012164 (32%) |species == rice; score == 142; expect == 5.6e-34; MEOW:gnl|TIGR|8352.m04835 (35%) } # EOR GENR { RETE|ID 1 HUgn0000028 CHR 1 9 DID 1 LocusLink:28 MAP 1 9q34.1-q34.2 NAM 1 ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) ORG 1 Homo sapiens SYM 1 ABO ID|HUgn0000028 DID|LocusLink:28 ORG|Homo sapiens RSQ|REFSEQ:NM_020469 RPA|REFPROT:NP_065202 DBA|XM:NM_020469 |NA:AC000397 |NA:AF134420 |NA:AF134422 |NA:AF170888 |NA:U22302 |NA:X84746 |NA:AF134412 |NA:AF134413 |NA:AF134414 |NA:AF134415 |NA:AF134416 |NA:J05175 |NA:U15197 |NA:none PAC|XP:NP_065202 SYM|ABO NAM|ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) FNC|ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) CHR|9 PRD|GTB URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=113271 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=28[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:118956 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_020469 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_020469 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00601 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00601 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00601 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00602 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00602 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00602 |http://www.bioc.aecom.yu.edu/bgmut/abo.htm DBL|UNIGENE:Hs.113271 |OMIM:110300 |SNP:28 ENZ|EC:2.4.1.37 |EC:2.4.1.40 MAP|9q34.1-q34.2 PHP|Blood group, ABO system HG|species == chimp; score == 666; expect == 0.0; MEOW:sp|Q9TUD9|Q9TUD9 (97%) |species == chimp; score == 624; expect == 0.0; MEOW:sp|Q9TTN2|Q9TTN2 (98%) |species == chimp; score == 588; expect == 1e-168; MEOW:sp|O97551|O97551 (96%) |species == chimp; score == 558; expect == 1e-159; MEOW:sp|O97549|O97549 (98%) |species == rat; score == 496; expect == 1e-140; MEOW:ref|XP_231041.2| (74%) |species == rat; score == 484; expect == 4e-137; MEOW:ref|XP_215986.1| (80%) |species == rat; score == 483; expect == 6e-137; MEOW:ref|XP_342395.1| (79%) |species == Mouse; gene == Abo; score == 450; expect == 3e-127; MEOW:MGgn0028359 (70%) |species == Human; gene == FS; score == 284; expect == 4.4e-77; MEOW:HUgn0026301 (49%) |species == Human; gene == LOC342885; score == 228; expect == 2.5e-60; MEOW:HUgn0342885 (59%) } # EOR GENR { RETE|ID 1 HUgn0000029 CHR 1 17 DID 1 LocusLink:29 MAP 1 17p13.3 NAM 1 active BCR-related gene ORG 1 Homo sapiens SYM 1 ABR ID|HUgn0000029 DID|LocusLink:29 ORG|Homo sapiens RSQ|REFSEQ:NM_001092 |REFSEQ:NM_021962 RPA|REFPROT:NP_001083 |REFPROT:NP_068781 DBA|XM:NM_001092 |XM:NM_021962 |NA:L19704 |NA:L19705 |NA:AK124547 |NA:AK126882 |NA:BC036807 |NA:U01147 |NA:none PAC|XP:NP_001083 |XP:NP_068781 SYM|ABR NAM|active BCR-related gene SYN|MDB FNC|active breakpoint cluster region-related protein isoform a |active breakpoint cluster region-related protein isoform b |small GTPase mediated signal transduction ; GO:0007264 REAB|Active breakpoint cluster region-related gene has homology with the breakpoint cluster |region gene located on chromosome 22. BCR is involved in reciprocal translocations |with the ABL oncogene on chromosome 9 in Philadelphia chromosome-positive chronic |myelogenous leukemia. These proteins might interact simultaneously and/or sequentially |with members of the Rho family to regulate and coordinate cellular signaling. Active |breakpoint cluster region-related protein may be associated with medulloblastoma. |This gene has two different alternatively spliced transcript variants. CHR|17 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=434004 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=29[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:119642 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_021962 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_021962 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=434004 DBL|UNIGENE:Hs.434004 |OMIM:600365 |SNP:29 MAP|17p13.3 ENZ|GTPase activator activity ; GO:0005096 |guanyl-nucleotide exchange factor activity ; GO:0005085 HG|species == rat; score == 1553; expect == 0.0; MEOW:ref|XP_220717.2| (96%) |species == Human; gene == BCR; score == 1102; expect == 0.0; MEOW:HUgn0000613 (69%) |species == Mosquito; score == 310; expect == 1.2e-84; MEOW:AGgn0017783 (36%) |species == Fruitfly; gene == RhoGAP1A; score == 269; expect == 2.4e-72; MEOW:FBgn0025836 (35%) } # EOR GENR { RETE|ID 1 HUgn0000030 CHR 1 3 DID 1 LocusLink:30 MAP 1 3p23-p22 NAM 1 acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) ORG 1 Homo sapiens SYM 1 ACAA1 ID|HUgn0000030 DID|LocusLink:30 ORG|Homo sapiens RSQ|REFSEQ:NM_001607 RPA|REFPROT:NP_001598 DBA|XM:NM_001607 |NA:X65140 |NA:X65148 |NA:AF035295 |NA:AK025138 |NA:AK127051 |NA:BC000635 |NA:BC011977 |NA:BC014474 |NA:BC025780 |NA:BC039837 |NA:X12966 |NA:X14813 |NA:X51460 |NA:none PAC|XP:NP_001598 SYM|ACAA1 NAM|acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) SYN|ACAA |THIO |PTHIO FNC|acetyl-Coenzyme A acyltransferase 1 |energy pathways ; GO:0006091 REAB|Acetyl-Coenzyme A acyltransferase (ACAA1) is an enzyme operative in the beta-oxidation |system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger |syndrome CHR|3 PRD|peroxisomal 3-oxoacyl-Coenzyme A thiolase |Acetyl-Coenzyme A acyltransferase (peroxisomal 3-oxoacyl-Coenzyme A |acetyl-Coenzyme A acyltransferase (peroxisomal 3-oxoacyl-Coenzyme A thiolase) URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=166160 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=30[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:119643 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_001607 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001607 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=166160 |http://tango01.cit.nih.gov/mitodat/search.taf?_function=list&locusid=30 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00071 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00120 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00360 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00062 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00362 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00280 |http://www.pharmgkb.org/do/serve?objCls=Gene&objId=PA24419 DBL|UNIGENE:Hs.166160 |OMIM:604054 |SNP:30 ENZ|EC:2.3.1.16 MAP|3p23-p22 PHP|Pseudo-Zellweger syndrome CEL|peroxisome ; GO:0005777 HG|species == rat; score == 699; expect == 0.0; MEOW:ref|NP_036621.1| (86%) |species == Mouse; gene == Acaa1; score == 696; expect == 0.0; MEOW:MGgn0030069 (85%) |species == rat; score == 694; expect == 0.0; MEOW:ref|XP_345998.1| (86%) |species == Weed; gene == At1g04710; score == 448; expect == 3e-126; MEOW:ATgn0005541 (56%) |species == rice; score == 442; expect == 4e-124; MEOW:gnl|TIGR|8351.m05505 (56%) |species == Weed; gene == At2g33150; score == 434; expect == 3e-122; MEOW:ATgn0010340 (55%) |species == rice; score == 433; expect == 2e-121; MEOW:gnl|TIGR|8362.m02423 (56%) |species == Weed; gene == At5g48880; score == 431; expect == 3e-121; MEOW:ATgn0022657 (58%) |species == Yeast; gene == POT1; score == 362; expect == 3e-100; MEOW:SGgn0001422 (51%) |species == ecoli; score == 247; expect == 9.3e-66; MEOW:ref|NP_417321.1| (37%) |species == Human; gene == ACAT2; score == 245; expect == 4.6e-65; MEOW:HUgn0000039 (41%) |species == ecoli; score == 245; expect == 4.6e-66; MEOW:ref|NP_418287.1| (42%) |species == Zfish; gene == acat2; score == 243; expect == 1.8e-64; MEOW:ZFgn0000284 (40%) |species == ecoli; score == 243; expect == 1.7e-65; MEOW:ref|NP_416728.1| (41%) |species == ecoli; score == 240; expect == 8.8e-64; MEOW:ref|NP_415915.1| (40%) |species == Mosquito; gene == LOC20372; score == 233; expect == 1.4e-61; MEOW:AGgn0020372 (38%) |species == Mosquito; gene == LOC13285; score == 229; expect == 1.6e-60; MEOW:AGgn0013285 (40%) |species == Worm; gene == F53A2.7; score == 224; expect == 4.9e-59; MEOW:CEgn0011549 (39%) |species == Human; gene == ACAA2; score == 219; expect == 3.0e-57; MEOW:HUgn0010449 (38%) |species == Mosquito; gene == LOC14645; score == 200; expect == 6.1e-52; MEOW:AGgn0014645 (43%) |species == Human; gene == HADHB; score == 197; expect == 1.1e-50; MEOW:HUgn0003032 (33%) |species == Fruitfly; gene == CG10932; score == 172; expect == 4.0e-43; MEOW:FBgn0029969 (32%) |species == Fruitfly; gene == Thiolase; score == 169; expect == 3.1e-42; MEOW:FBgn0025352 (32%) } # EOR GENR { RETE|ID 1 HUgn0000031 CHR 1 17 DID 1 LocusLink:31 MAP 1 17q21 NAM 1 acetyl-Coenzyme A carboxylase alpha ORG 1 Homo sapiens SYM 1 ACACA ID|HUgn0000031 DID|LocusLink:31 ORG|Homo sapiens RSQ|REFSEQ:NM_000664 RPA|REFPROT:NP_000655 DBA|XM:NM_000664 |NA:AY315616 |NA:AY315617 |NA:AY315618 |NA:AK129523 |NA:AY315619 |NA:AY315620 |NA:AY315621 |NA:AY315622 |NA:AY315623 |NA:AY315624 |NA:AY315625 |NA:AY315626 |NA:AY315627 |NA:BC031485 |NA:BC041598 |NA:BF154865 |NA:U19822 |NA:none PAC|XP:NP_000655 SYM|ACACA NAM|acetyl-Coenzyme A carboxylase alpha SYN|ACC |ACAC |ACC1 |ACCA FNC|acetyl-Coenzyme A carboxylase alpha |metabolism ; GO:0008152 |fatty acid biosynthesis ; GO:0006633 REAB|Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is |a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, |the rate-limiting step in fatty acid synthesis. ACC-alpha is highly enriched in |lipogenic tissues and is under long term control at the transcriptional and translational |levels and under short term regulation by the phosphorylation/dephosphorylation |of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. CHR|17 DBL|OMIM:200350 |SNP:31 ENZ|EC:6.4.1.2 |biotin carboxylase activity ; GO:0004075 |biotin binding ; GO:0009374 |acetyl-CoA carboxylase activity ; GO:0003989 |ATP binding ; GO:0005524 |ligase activity ; GO:0016874 MAP|17q21 PHP|Acetyl-CoA carboxylase deficiency URL|http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=31[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:120534 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_000664 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_000664 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00620 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00640 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00253 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00061 CEL|biotin carboxylase complex ; GO:0009343 HG|species == rat; score == 4518; expect == 0.0; MEOW:ref|NP_071529.1| (97%) |species == Human; gene == ACACB; score == 3361; expect == 0.0; MEOW:HUgn0000032 (72%) |species == Mosquito; gene == LOC15662; score == 2808; expect == 0.0; MEOW:AGgn0015662 (61%) |species == Fruitfly; gene == CG11198; score == 2773; expect == 0.0; MEOW:FBgn0033246 (61%) |species == Yeast; gene == ACC1; score == 1788; expect == 0.0; MEOW:SGgn0005299 (44%) |species == Yeast; gene == HFA1; score == 1614; expect == 0.0; MEOW:SGgn0004820 (42%) |species == rice; score == 1516; expect == 0.0; MEOW:gnl|TIGR|8362.m01633 (39%) |species == Weed; gene == At1g36160; score == 1476; expect == 0.0; MEOW:ATgn0006015 (38%) |species == rice; score == 1450; expect == 0.0; MEOW:gnl|TIGR|8353.m01895 (37%) |species == Worm; gene == W09B6.1; score == 604; expect == 2e-172; MEOW:CEgn0017778 (43%) |species == Worm; gene == T28F3.5; score == 530; expect == 4e-150; MEOW:CEgn0017221 (41%) |species == Mouse; gene == Pcca; score == 237; expect == 2.0e-62; MEOW:MGgn0008812 (28%) |species == ecoli; score == 237; expect == 6.0e-63; MEOW:ref|NP_417722.1| (31%) |species == Mouse; gene == Mccc1; score == 234; expect == 3.0e-61; MEOW:MGgn0018765 (31%) |species == Mouse; gene == Pcx; score == 222; expect == 1.5e-57; MEOW:MGgn0008853 (30%) |species == Zfish; gene == pc; score == 208; expect == 1.3e-54; MEOW:ZFgn0000870 (28%) } # EOR GENR { RETE|ID 1 HUgn0000032 CHR 1 12 DID 1 LocusLink:32 MAP 1 12q24.1 NAM 1 acetyl-Coenzyme A carboxylase beta ORG 1 Homo sapiens SYM 1 ACACB ID|HUgn0000032 DID|LocusLink:32 ORG|Homo sapiens RSQ|REFSEQ:NM_001093 RPA|REFPROT:NP_001084 DBA|XM:NM_001093 |NA:U34591 |NA:U89344 |NA:none PAC|XP:NP_001084 SYM|ACACB NAM|acetyl-Coenzyme A carboxylase beta SYN|ACC2 |ACCB |HACC275 FNC|acetyl-Coenzyme A carboxylase beta |metabolism ; GO:0008152 |fatty acid biosynthesis ; GO:0006633 REAB|Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a |biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, |the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control |fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA |transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. | ACC-beta may be involved in the regulation of fatty acid oxidation, rather than |fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. CHR|12 DBL|OMIM:601557 |SNP:32 ENZ|EC:6.4.1.2 |EC:6.3.4.14 |biotin carboxylase activity ; GO:0004075 |biotin binding ; GO:0009374 |acetyl-CoA carboxylase activity ; GO:0003989 |ATP binding ; GO:0005524 |ligase activity ; GO:0016874 MAP|12q24.1 URL|http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=32[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:5200247 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_001093 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001093 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00620 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00640 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00253 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00061 CEL|biotin carboxylase complex ; GO:0009343 HG|species == rat; score == 3395; expect == 0.0; MEOW:ref|NP_071529.1| (73%) |species == Human; gene == ACACA; score == 3361; expect == 0.0; MEOW:HUgn0000031 (72%) |species == rat; score == 3285; expect == 0.0; MEOW:ref|XP_346442.1| (85%) |species == Mosquito; gene == LOC15662; score == 2682; expect == 0.0; MEOW:AGgn0015662 (58%) |species == Fruitfly; gene == CG11198; score == 2656; expect == 0.0; MEOW:FBgn0033246 (59%) |species == Yeast; gene == ACC1; score == 1744; expect == 0.0; MEOW:SGgn0005299 (45%) |species == Yeast; gene == HFA1; score == 1552; expect == 0.0; MEOW:SGgn0004820 (41%) |species == rice; score == 1435; expect == 0.0; MEOW:gnl|TIGR|8362.m01633 (38%) |species == Weed; gene == At1g36160; score == 1401; expect == 0.0; MEOW:ATgn0006015 (38%) |species == rice; score == 1385; expect == 0.0; MEOW:gnl|TIGR|8353.m01895 (37%) |species == Worm; gene == W09B6.1; score == 578; expect == 1e-164; MEOW:CEgn0017778 (44%) |species == Worm; gene == T28F3.5; score == 502; expect == 6e-142; MEOW:CEgn0017221 (39%) |species == Mouse; gene == Pcca; score == 217; expect == 2.1e-56; MEOW:MGgn0008812 (26%) |species == Mouse; gene == Mccc1; score == 211; expect == 2.8e-54; MEOW:MGgn0018765 (27%) |species == ecoli; score == 209; expect == 1.9e-54; MEOW:ref|NP_417722.1| (30%) |species == Mouse; gene == Pcx; score == 196; expect == 1.2e-49; MEOW:MGgn0008853 (29%) |species == Zfish; gene == pc; score == 188; expect == 1.9e-48; MEOW:ZFgn0000870 (29%) } # EOR GENR { RETE|ID 1 HUgn0000033 CHR 1 2 DID 1 LocusLink:33 MAP 1 2q34-q35 NAM 1 acyl-Coenzyme A dehydrogenase, long chain ORG 1 Homo sapiens SYM 1 ACADL ID|HUgn0000033 DID|LocusLink:33 ORG|Homo sapiens RSQ|REFSEQ:NM_001608 RPA|REFPROT:NP_001599 DBA|XM:NM_001608 |NA:BC039063 |NA:M74096 |NA:none PAC|XP:NP_001599 SYM|ACADL NAM|acyl-Coenzyme A dehydrogenase, long chain SYN|LCAD |ACAD4 FNC|acyl-Coenzyme A dehydrogenase, long chain precursor REAB|Long-chain acyl-coA dehydrogenase (ACADL), also abbreviated as LCAD, is a mitochondrial |metrix enzyme involved in catalyzing the first reaction in the mitochondrial beta-oxidation |cycles for fatty acids. Two other acyl-coA dehydrogenases are also involved in |fatty acid oxidation, medium chain and short chain ALDs. However, of these ACADL |catalyzes the first and critical step in this process. ACADL is a homotetrameic |enzyme of 45-kDa. It is synthesized in the cytoplasm a a precursor then processed |and targeted to the mitochondria. Genetic deficiency of ACADL is associated with |severe hypoglycemia, skeletal muscle weakness, hepatomegaly and cardiomegaly, which |can be fatal. CHR|2 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=430108 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=33[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:118745 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_001608 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001608 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=430108 |http://www.geneclinics.org/query?mim=201460 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00071 DBL|UNIGENE:Hs.430108 |OMIM:201460 |SNP:33 ENZ|EC:1.3.99.13 MAP|2q34-q35 PHP|Acyl-CoA dehydrogenase, long chain, deficiency of HG|species == Mouse; gene == Acadl; score == 748; expect == 0.0; MEOW:MGgn0000037 (86%) |species == rat; score == 734; expect == 0.0; MEOW:ref|NP_036951.1| (87%) |species == Human; gene == IVD; score == 240; expect == 1.2e-63; MEOW:HUgn0003712 (34%) |species == Fruitfly; gene == CG6638; score == 224; expect == 4.2e-59; MEOW:FBgn0035911 (33%) |species == Human; gene == ACADSB; score == 216; expect == 2.0e-56; MEOW:HUgn0000036 (33%) |species == Weed; gene == At3g45300; score == 214; expect == 5.7e-56; MEOW:ATgn0012521 (32%) |species == Mosquito; gene == LOC19082; score == 212; expect == 1.6e-55; MEOW:AGgn0019082 (32%) |species == Fruitfly; gene == CG12262; score == 212; expect == 1.7e-55; MEOW:FBgn0035811 (33%) |species == Worm; gene == C02B10.1; score == 211; expect == 5.6e-55; MEOW:CEgn0003792 (32%) |species == Worm; gene == T25G12.5; score == 211; expect == 3.3e-55; MEOW:CEgn0016968 (35%) |species == rice; score == 211; expect == 1.8e-54; MEOW:gnl|TIGR|8353.m00250 (31%) |species == Human; gene == ACADM; score == 210; expect == 1.0e-54; MEOW:HUgn0000034 (32%) |species == Human; gene == ACADS; score == 210; expect == 1.1e-54; MEOW:HUgn0000035 (32%) |species == Worm; gene == C37A2.3; score == 207; expect == 8.2e-54; MEOW:CEgn0006152 (32%) |species == Mosquito; gene == LOC21837; score == 205; expect == 1.9e-53; MEOW:AGgn0021837 (33%) |species == Worm; gene == C55B7.4a; score == 205; expect == 3.1e-53; MEOW:CEgn0031838 (33%) |species == Fruitfly; gene == Arc42; score == 205; expect == 2.0e-53; MEOW:FBgn0038742 (32%) |species == Human; gene == ACAD8; score == 199; expect == 1.8e-51; MEOW:HUgn0027034 (32%) |species == Fruitfly; gene == CG3902; score == 198; expect == 3.2e-51; MEOW:FBgn0036824 (31%) |species == Mosquito; gene == LOC15771; score == 197; expect == 5.3e-51; MEOW:AGgn0015771 (31%) |species == Worm; gene == F28A10.6; score == 196; expect == 1.9e-50; MEOW:CEgn0009492 (32%) |species == Worm; gene == C02D5.1; score == 195; expect == 3.2e-50; MEOW:CEgn0003809 (31%) |species == Worm; gene == K06A5.6; score == 195; expect == 3.2e-50; MEOW:CEgn0013313 (30%) |species == Worm; gene == T08G2.3; score == 195; expect == 3.2e-50; MEOW:CEgn0015823 (31%) |species == Worm; gene == K05F1.3; score == 194; expect == 4.2e-50; MEOW:CEgn0013276 (31%) |species == Mosquito; score == 184; expect == 4.6e-47; MEOW:AGgn0000447 (30%) |species == Mosquito; gene == LOC13168; score == 184; expect == 3.5e-47; MEOW:AGgn0013168 (32%) |species == Mosquito; score == 181; expect == 3.0e-46; MEOW:AGgn0020214 (40%) |species == Worm; gene == T10E9.9; score == 171; expect == 3.7e-43; MEOW:CEgn0015993 (32%) |species == ecoli; score == 155; expect == 4.9e-38; MEOW:ref|NP_416210.1| (29%) |species == ecoli; score == 133; expect == 1.9e-31; MEOW:ref|NP_414581.1| (25%) } # EOR GENR { RETE|ID 1 HUgn0000034 CHR 1 1 DID 1 LocusLink:34 MAP 1 1p31 NAM 1 acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain ORG 1 Homo sapiens SYM 1 ACADM ID|HUgn0000034 DID|LocusLink:34 ORG|Homo sapiens RSQ|REFSEQ:NM_000016 RPA|REFPROT:NP_000007 DBA|XM:NM_000016 |NA:M60505 |NA:M91432 |NA:U33947 |NA:AF251043 |NA:BC005377 |NA:BX647734 |NA:M16827 |NA:none PAC|XP:NP_000007 SYM|ACADM NAM|acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain SYN|MCAD |ACAD1 |MCADH FNC|acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain |fatty acid beta-oxidation ; GO:0006635 |electron transport ; GO:0006118 |fatty acid metabolism ; GO:0006631 |energy pathways ; GO:0006091 REAB|This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme |A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial |fatty acid beta-oxidation pathway. Clinical phenotypes are associated with ACADM |hereditary deficiency. CHR|1 PRD|medium-chain acyl-CoA dehydrogenase URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=254593 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=34[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:118958 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_000016 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_000016 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=254593 |http://www.geneclinics.org/query?mim=201450 |http://www.geneclinics.org/query?mim=607008 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00071 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00640 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00410 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00280 DBL|UNIGENE:Hs.254593 |OMIM:607008 |SNP:34 |UWCM:118958.html ENZ|EC:1.3.99.3 |acyl-CoA dehydrogenase activity ; GO:0003995 |oxidoreductase activity ; GO:0016491 MAP|1p31 PHP|Acyl-CoA dehydrogenase, medium chain, deficiency of CEL|mitochondrial matrix ; GO:0005759 HG|species == Mouse; gene == Acadm; score == 765; expect == 0.0; MEOW:MGgn0000038 (87%) |species == rat; score == 753; expect == 0.0; MEOW:ref|NP_058682.1| (86%) |species == Fruitfly; gene == CG12262; score == 587; expect == 2e-168; MEOW:FBgn0035811 (69%) |species == Mosquito; gene == LOC21837; score == 574; expect == 2e-164; MEOW:AGgn0021837 (70%) |species == Worm; gene == T08G2.3; score == 495; expect == 1e-140; MEOW:CEgn0015823 (64%) |species == Worm; gene == T25G12.5; score == 495; expect == 1e-140; MEOW:CEgn0016968 (63%) |species == Worm; gene == K05F1.3; score == 480; expect == 4e-136; MEOW:CEgn0013276 (61%) |species == Human; gene == ACADS; score == 264; expect == 6.1e-71; MEOW:HUgn0000035 (37%) |species == Human; gene == ACADSB; score == 245; expect == 3.8e-65; MEOW:HUgn0000036 (37%) |species == Human; gene == ACAD8; score == 236; expect == 2.3e-62; MEOW:HUgn0027034 (33%) |species == Weed; gene == At3g45300; score == 228; expect == 6.4e-60; MEOW:ATgn0012521 (35%) |species == Human; gene == IVD; score == 228; expect == 3.7e-60; MEOW:HUgn0003712 (34%) |species == rice; score == 226; expect == 5.3e-59; MEOW:gnl|TIGR|8353.m00250 (36%) |species == ecoli; score == 157; expect == 1.2e-38; MEOW:ref|NP_414581.1| (28%) |species == ecoli; score == 156; expect == 1.7e-38; MEOW:ref|NP_416210.1| (29%) } # EOR GENR { RETE|ID 1 HUgn0000035 CHR 1 12 DID 1 LocusLink:35 MAP 1 12q22-qter NAM 1 acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain ORG 1 Homo sapiens SYM 1 ACADS ID|HUgn0000035 DID|LocusLink:35 ORG|Homo sapiens RSQ|REFSEQ:NM_000017 RPA|REFPROT:NP_000008 DBA|XM:NM_000017 |NA:Z80345 |NA:Z80347 |NA:BC025963 |NA:M26393 |NA:none PAC|XP:NP_000008 SYM|ACADS NAM|acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain SYN|SCAD |ACAD3 FNC|acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain precursor |fatty acid beta-oxidation ; GO:0006635 |electron transport ; GO:0006118 |fatty acid metabolism ; GO:0006631 |energy pathways ; GO:0006091 REAB|The nuclear ACADS gene encodes a mitochondrially-targeted protein product. Acyl-Coenzyme |A dehydrogenase, short-chain specific, catalyzes the initial step of the mitochondrial |fatty acid beta-oxidation pathway. Clinical phenotypes, described elsewhere, are |associated with ACADS hereditary deficiency. CHR|12 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=348900 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=35[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:118959 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_000017 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_000017 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=348900 |http://www.geneclinics.org/query?mim=201470 |http://www.geneclinics.org/query?mim=606885 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00650 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00071 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00280 DBL|UNIGENE:Hs.348900 |OMIM:606885 |SNP:35 |UWCM:118959.html ENZ|EC:1.3.99.2 |butyryl-CoA dehydrogenase activity ; GO:0004085 |oxidoreductase activity ; GO:0016491 MAP|12q22-qter PHP|Acyl-CoA dehydrogenase, short-chain, deficiency of CEL|mitochondrion ; GO:0005739 HG|species == rat; score == 683; expect == 0.0; MEOW:ref|NP_071957.1| (91%) |species == Mouse; gene == Acads; score == 680; expect == 0.0; MEOW:MGgn0000041 (91%) |species == Mosquito; gene == LOC19082; score == 548; expect == 2e-156; MEOW:AGgn0019082 (74%) |species == Fruitfly; gene == Arc42; score == 528; expect == 1e-150; MEOW:FBgn0038742 (73%) |species == Human; gene == ACADSB; score == 287; expect == 1.2e-77; MEOW:HUgn0000036 (41%) |species == Worm; gene == K06A5.6; score == 286; expect == 1.5e-77; MEOW:CEgn0013313 (41%) |species == Worm; gene == C55B7.4a; score == 282; expect == 3.8e-76; MEOW:CEgn0031838 (40%) |species == Worm; gene == C02B10.1; score == 270; expect == 8.4e-73; MEOW:CEgn0003792 (38%) |species == Worm; gene == T08G2.3; score == 265; expect == 4.6e-71; MEOW:CEgn0015823 (39%) |species == Human; gene == ACADM; score == 264; expect == 6.1e-71; MEOW:HUgn0000034 (37%) |species == Worm; gene == T25G12.5; score == 263; expect == 1.0e-70; MEOW:CEgn0016968 (39%) |species == Worm; gene == K05F1.3; score == 261; expect == 3.8e-70; MEOW:CEgn0013276 (39%) |species == Human; gene == IVD; score == 258; expect == 5.7e-69; MEOW:HUgn0003712 (38%) |species == rice; score == 252; expect == 5.1e-67; MEOW:gnl|TIGR|8353.m00250 (37%) |species == Human; gene == ACAD8; score == 250; expect == 8.9e-67; MEOW:HUgn0027034 (37%) |species == Weed; gene == At3g45300; score == 244; expect == 8.2e-65; MEOW:ATgn0012521 (38%) |species == Worm; gene == F28A10.6; score == 235; expect == 5.0e-62; MEOW:CEgn0009492 (37%) |species == Worm; gene == T10E9.9; score == 235; expect == 3.6e-62; MEOW:CEgn0015993 (43%) |species == ecoli; score == 175; expect == 3.5e-44; MEOW:ref|NP_416210.1| (30%) |species == ecoli; score == 163; expect == 1.7e-40; MEOW:ref|NP_414581.1| (29%) } # EOR GENR { RETE|ID 1 HUgn0000036 CHR 1 10 DID 1 LocusLink:36 MAP 1 10q25-q26 NAM 1 acyl-Coenzyme A dehydrogenase, short/branched chain ORG 1 Homo sapiens SYM 1 ACADSB ID|HUgn0000036 DID|LocusLink:36 ORG|Homo sapiens RSQ|REFSEQ:NM_001609 RPA|REFPROT:NP_001600 DBA|XM:NM_001609 |NA:AL831821 |NA:BC013756 |NA:BC020931 |NA:BC032395 |NA:BC045723 |NA:BE875638 |NA:U12778 |NA:none PAC|XP:NP_001600 SYM|ACADSB NAM|acyl-Coenzyme A dehydrogenase, short/branched chain SYN|ACAD7 |SBCAD |2-MEBCAD FNC|acyl-Coenzyme A dehydrogenase, short/branched chain precursor |electron transport ; GO:0006118 |fatty acid metabolism ; GO:0006631 |energy pathways ; GO:0006091 REAB|Short/branched chain acyl-CoA dehydrogenase(ACADSB) is a member of the acyl-CoA dehydrogenase |family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the |metabolism of fatty acids or branch chained amino acids. Substrate specificity is |the primary characteristic used to define members of this gene family. The ACADSB |gene product has the greatest activity towards the short branched chain acyl-CoA |derivative, (S)-2-methylbutyryl-CoA, but also reacts significantly with other 2-methyl |branched chain substrates and with short straight chain acyl-CoAs. The cDNA encodes |for a mitochondrial precursor protein which is cleaved upon mitochondrial import |and predicted to yield a mature peptide of approximately 43.7-KDa. CHR|10 PRD|2-methylbutyryl-CoA dehydrogenase |2-methyl branched chain acyl-CoA dehydrogenase URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=81934 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=36[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:388699 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_001609 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001609 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=81934 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00071 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00640 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00120 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00410 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00600 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00280 DBL|UNIGENE:Hs.81934 |OMIM:600301 |SNP:36 MAP|10q25-q26 ENZ|acyl-CoA dehydrogenase activity ; GO:0003995 |oxidoreductase activity ; GO:0016491 CEL|mitochondrion ; GO:0005739 HG|species == rat; score == 726; expect == 0.0; MEOW:ref|NP_037216.1| (84%) |species == Mouse; gene == Acadsb; score == 719; expect == 0.0; MEOW:MGgn0016625 (83%) |species == Fruitfly; gene == CG3902; score == 497; expect == 3e-141; MEOW:FBgn0036824 (62%) |species == Worm; gene == K06A5.6; score == 489; expect == 1e-138; MEOW:CEgn0013313 (61%) |species == Mosquito; gene == LOC15771; score == 485; expect == 2e-137; MEOW:AGgn0015771 (60%) |species == Worm; gene == C55B7.4a; score == 454; expect == 4e-128; MEOW:CEgn0031838 (56%) |species == Human; gene == ACADS; score == 287; expect == 1.2e-77; MEOW:HUgn0000035 (41%) |species == Human; gene == ACADM; score == 245; expect == 3.8e-65; MEOW:HUgn0000034 (37%) |species == Human; gene == IVD; score == 244; expect == 8.6e-65; MEOW:HUgn0003712 (33%) |species == Weed; gene == At3g45300; score == 240; expect == 1.7e-63; MEOW:ATgn0012521 (37%) |species == rice; score == 233; expect == 3.4e-61; MEOW:gnl|TIGR|8353.m00250 (34%) |species == ecoli; score == 162; expect == 2.2e-40; MEOW:ref|NP_414581.1| (26%) |species == ecoli; score == 142; expect == 3.3e-34; MEOW:ref|NP_416210.1| (26%) } # EOR GENR { RETE|ID 1 HUgn0000037 CHR 1 17 DID 1 LocusLink:37 MAP 1 17p13-p11 NAM 1 acyl-Coenzyme A dehydrogenase, very long chain ORG 1 Homo sapiens SYM 1 ACADVL ID|HUgn0000037 DID|LocusLink:37 ORG|Homo sapiens RSQ|REFSEQ:NM_000018 RPA|REFPROT:NP_000009 DBA|XM:NM_000018 |NA:AF244932 |NA:AJ012053 |NA:D78298 |NA:L46590 |NA:AK056083 |NA:AK056956 |NA:AK058109 |NA:AK097243 |NA:BC000399 |NA:BC012912 |NA:BC020218 |NA:D43682 |NA:X86556 |NA:none PAC|XP:NP_000009 SYM|ACADVL NAM|acyl-Coenzyme A dehydrogenase, very long chain SYN|ACAD6 |LCACD |VLCAD FNC|acyl-Coenzyme A dehydrogenase, very long chain precursor |fatty acid beta-oxidation ; GO:0006635 |energy derivation by oxidation of organic compounds ; GO:0015980 |electron transport ; GO:0006118 |fatty acid metabolism ; GO:0006631 REAB|The ACADVL gene product is targetted to the inner mitochondrial membrane where it |catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. | This acyl-Coenzyme A dehydrogenase is specific to long-chain and very long-chain |fatty acids. ACADVL deficiency reduces myocardial fatty acid beta-oxidation and |is associated with cardiomyopathy. CHR|17 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=437178 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=37[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:1248185 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_000018 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_000018 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=437178 |http://www.geneclinics.org/query?mim=201475 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00100 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00120 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00900 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00360 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00600 DBL|UNIGENE:Hs.437178 |OMIM:201475 |SNP:37 |UWCM:1248185.html MAP|17p13-p11 PHP|VLCAD deficiency ENZ|long-chain-acyl-CoA dehydrogenase activity ; GO:0004466 |oxidoreductase activity ; GO:0016491 CEL|mitochondrion ; GO:0005739 HG|species == rat; score == 1056; expect == 0.0; MEOW:ref|NP_037023.1| (85%) |species == Mouse; gene == Acadvl; score == 1044; expect == 0.0; MEOW:MGgn0000042 (84%) |species == Fruitfly; gene == CG7461; score == 660; expect == 0.0; MEOW:FBgn0034432 (57%) |species == Mosquito; score == 617; expect == 5e-177; MEOW:AGgn0012480 (60%) |species == Mosquito; score == 558; expect == 2e-159; MEOW:AGgn0012475 (61%) |species == Worm; gene == E04F6.5; score == 541; expect == 4e-154; MEOW:CEgn0007606 (48%) |species == Human; gene == ACAD9; score == 503; expect == 2e-142; MEOW:HUgn0028976 (46%) |species == Weed; gene == At3g45300; score == 198; expect == 7.0e-51; MEOW:ATgn0012521 (32%) |species == rice; score == 198; expect == 2.6e-50; MEOW:gnl|TIGR|8353.m00250 (33%) |species == ecoli; score == 129; expect == 4.6e-31; MEOW:ref|NP_414581.1| (29%) } # EOR GENR { RETE|ID 1 HUgn0000038 CHR 1 11 DID 1 LocusLink:38 MAP 1 11q22.3-q23.1 NAM 1 acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) ORG 1 Homo sapiens SYM 1 ACAT1 ID|HUgn0000038 DID|LocusLink:38 ORG|Homo sapiens RSQ|REFSEQ:NM_000019 RPA|REFPROT:NP_000010 DBA|XM:NM_000019 |NA:D10511 |NA:BC010942 |NA:D90228 |NA:none PAC|XP:NP_000010 SYM|ACAT1 NAM|acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) SYN|T2 |MAT |ACAT |THIL FNC|acetyl-Coenzyme A acetyltransferase 1 precursor REAB|This gene encodes a mitochondrially localized enzyme that catalyzes the reversible |formation of acetoacetyl-CoA from two molecules of acetyl-CoA. This gene spans approximately |27 kb and contains 12 exons interrupted by 11 introns. Defects in this gene are |associated with the alpha-methylacetoaceticaciduria disorder, an inborn error of |isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric |acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. CHR|11 PRD|acetoacetyl Coenzyme A thiolase URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=37 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=38[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:126861 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_000019 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_000019 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=37 |http://tango01.cit.nih.gov/mitodat/search.taf?_function=list&locusid=38 |http://www.geneclinics.org/query?mim=203750 |http://www.geneclinics.org/query?mim=607809 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00310 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00620 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00650 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00071 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00640 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00380 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00062 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00632 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00072 DBL|UNIGENE:Hs.37 |OMIM:607809 |SNP:38 |UWCM:126861.html ENZ|EC:2.3.1.9 |acetyl-CoA C-acetyltransferase activity ; GO:0003985 MAP|11q22.3-q23.1 PHP|Alpha-methylacetoacetic aciduria CEL|mitochondrion ; GO:0005739 HG|species == Mouse; gene == Acat1; score == 693; expect == 0.0; MEOW:MGgn0000045 (84%) |species == rat; score == 691; expect == 0.0; MEOW:ref|NP_058771.1| (84%) |species == Mosquito; score == 510; expect == 3e-145; MEOW:AGgn0017971 (67%) |species == Fruitfly; gene == CG10932; score == 509; expect == 8e-145; MEOW:FBgn0029969 (65%) |species == Worm; gene == T02G5.7; score == 373; expect == 8e-104; MEOW:CEgn0015227 (49%) |species == Weed; gene == At5g47720; score == 369; expect == 1e-102; MEOW:ATgn0026318 (51%) |species == Weed; gene == At5g48230; score == 364; expect == 8e-101; MEOW:ATgn0021200 (51%) |species == rice; score == 342; expect == 6.7e-94; MEOW:gnl|TIGR|8357.m00537 (49%) |species == Yeast; gene == ERG10; score == 341; expect == 1.1e-94; MEOW:SGgn0005949 (48%) |species == rice; score == 318; expect == 7.9e-87; MEOW:gnl|TIGR|8350.m00101 (48%) |species == ecoli; score == 315; expect == 2.8e-86; MEOW:ref|NP_417321.1| (43%) |species == Zfish; gene == acat2; score == 305; expect == 3.8e-83; MEOW:ZFgn0000284 (42%) |species == Human; gene == ACAT2; score == 297; expect == 1.0e-80; MEOW:HUgn0000039 (43%) |species == ecoli; score == 282; expect == 3.4e-77; MEOW:ref|NP_416728.1| (44%) |species == Human; gene == ACAA2; score == 246; expect == 1.7e-65; MEOW:HUgn0010449 (39%) } # EOR GENR { RETE|ID 1 HUgn0000039 CHR 1 6 DID 1 LocusLink:39 MAP 1 6q25.3-q26 NAM 1 acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) ORG 1 Homo sapiens SYM 1 ACAT2 ID|HUgn0000039 DID|LocusLink:39 ORG|Homo sapiens RSQ|REFSEQ:NM_005891 RPA|REFPROT:NP_005882 DBA|XM:NM_005891 |NA:AF356877 |NA:AK055001 |NA:BC000408 |NA:S70154 PAC|XP:NP_005882 SYM|ACAT2 NAM|acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) FNC|acetyl-Coenzyme A acetyltransferase 2 |lipid metabolism ; GO:0006629 REAB|Acetyl-Coenzyme A acetyltransferase 2 is an enzyme involved in lipid metabolism. | Reported patients with ACAT2 deficiency have shown severe mental retardation and |hypotonus. The ACAT2 gene shows complementary overlapping with the 3-prime region |of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands |of DNA, as well as in opposite transcriptional orientation. CHR|6 PRD|acetoacetyl Coenzyme A thiolase URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=278544 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=39[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:321951 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_005891 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_005891 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=278544 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00310 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00620 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00650 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00071 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00640 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00380 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00062 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00632 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00072 DBL|UNIGENE:Hs.278544 |OMIM:100678 |SNP:39 MAP|6q25.3-q26 CEL|cytoplasm ; GO:0005737 HG|species == Mouse; gene == Acat2; score == 697; expect == 0.0; MEOW:MGgn0000046 (87%) |species == rat; score == 693; expect == 0.0; MEOW:ref|XP_217796.2| (86%) |species == rat; score == 586; expect == 2e-167; MEOW:ref|XP_344813.1| (85%) |species == Zfish; gene == acat2; score == 569; expect == 1e-162; MEOW:ZFgn0000284 (70%) |species == Mosquito; gene == LOC20372; score == 452; expect == 8e-128; MEOW:AGgn0020372 (57%) |species == ecoli; score == 388; expect == 3e-109; MEOW:ref|NP_416728.1| (53%) |species == ecoli; score == 364; expect == 5e-101; MEOW:ref|NP_417321.1| (48%) |species == Weed; gene == At5g48230; score == 314; expect == 4.8e-86; MEOW:ATgn0021200 (46%) |species == Worm; gene == F53A2.7; score == 302; expect == 1.3e-82; MEOW:CEgn0011549 (42%) |species == Human; gene == ACAT1; score == 297; expect == 1.0e-80; MEOW:HUgn0000038 (43%) |species == Weed; gene == At5g47720; score == 293; expect == 1.5e-79; MEOW:ATgn0026318 (44%) |species == Human; gene == ACAA2; score == 293; expect == 1.5e-79; MEOW:HUgn0010449 (42%) |species == rice; score == 293; expect == 2.5e-79; MEOW:gnl|TIGR|8357.m00537 (44%) |species == Yeast; gene == ERG10; score == 287; expect == 1.8e-78; MEOW:SGgn0005949 (41%) |species == Fruitfly; gene == CG10932; score == 283; expect == 5.3e-77; MEOW:FBgn0029969 (41%) |species == Worm; gene == T02G5.7; score == 269; expect == 1.2e-72; MEOW:CEgn0015227 (39%) |species == rice; score == 262; expect == 4.7e-70; MEOW:gnl|TIGR|8350.m00101 (40%) |species == rice; score == 246; expect == 3.5e-65; MEOW:gnl|TIGR|8351.m05505 (38%) |species == rice; score == 246; expect == 2.7e-65; MEOW:gnl|TIGR|8362.m02423 (40%) |species == Human; gene == ACAA1; score == 245; expect == 4.6e-65; MEOW:HUgn0000030 (41%) } # EOR GENR { RETE|ID 1 HUgn0000040 CHR 1 17 DID 1 LocusLink:40 MAP 1 17q11.2-q12 NAM 1 amiloride-sensitive cation channel 1, neuronal (degenerin) ORG 1 Homo sapiens SYM 1 ACCN1 ID|HUgn0000040 DID|LocusLink:40 ORG|Homo sapiens RSQ|REFSEQ:NM_001094 |REFSEQ:NM_183377 RPA|REFPROT:NP_001085 |REFPROT:NP_899233 DBA|XM:NM_001094 |NA:AK127748 |NA:AL834182 |NA:U50352 |NA:U53212 |NA:U57352 |NA:none PAC|XP:NP_001085 SYM|ACCN1 NAM|amiloride-sensitive cation channel 1, neuronal (degenerin) SYN|ACCN |BNC1 |MDEG |ASIC2 |BNaC1 |ASIC2a |hBNaC1 FNC|neuronal amiloride-sensitive cation channel 1 isoform 1 |neuronal amiloride-sensitive cation channel 1 isoform 2 REAB|This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) |superfamily. The members of this family are amiloride-sensitive sodium channels |that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, |and a large extracellular loop, which has many cysteine residues with conserved |spacing. The member encoded by this gene may play a role in neurotransmission. In |addition, a heteromeric association between this member and ACCN3 (variant 1) has |been observed to co-assemble into proton-gated channels sensitive to gadolinium. |Alternative splicing has been observed at this locus and two variants, encoding |distinct isoforms, have been identified. CHR|17 PRD|degenerin URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=6517 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=40[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:4645366 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_183377 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_183377 DBL|UNIGENE:Hs.6517 |OMIM:601784 |SNP:40 MAP|17q11.2-q12 HG|species == rat; score == 973; expect == 0.0; MEOW:ref|NP_037024.1| (99%) |species == Mouse; gene == Accn1; score == 741; expect == 0.0; MEOW:MGgn0000050 (78%) |species == Human; gene == ACCN2; score == 716; expect == 0.0; MEOW:HUgn0000041 (66%) |species == Worm; gene == mec-10; score == 137; expect == 1.3e-32; MEOW:CEgn0001940 (28%) |species == Worm; gene == flr-1; score == 136; expect == 3.2e-32; MEOW:CEgn0000689 (24%) |species == Worm; gene == C24G7.4; score == 136; expect == 4.3e-32; MEOW:CEgn0005283 (27%) |species == Worm; gene == unc-105; score == 135; expect == 1.3e-31; MEOW:CEgn0002985 (30%) |species == Worm; gene == unc-8; score == 133; expect == 4.4e-31; MEOW:CEgn0002894 (27%) } # EOR GENR { RETE|ID 1 HUgn0000041 CHR 1 12 DID 1 LocusLink:41 MAP 1 12q12 NAM 1 amiloride-sensitive cation channel 2, neuronal ORG 1 Homo sapiens SYM 1 ACCN2 ID|HUgn0000041 DID|LocusLink:41 ORG|Homo sapiens RSQ|REFSEQ:NM_001095 |REFSEQ:NM_020039 RPA|REFPROT:NP_001086 |REFPROT:NP_064423 DBA|XM:NM_001095 |XM:NM_020039 |NA:BC013891 |NA:U78180 |NA:U78181 |NA:none PAC|XP:NP_001086 |XP:NP_064423 SYM|ACCN2 NAM|amiloride-sensitive cation channel 2, neuronal SYN|ASIC |BNaC2 |ASIC1A FNC|amiloride-sensitive cation channel 2, neuronal isoform a |amiloride-sensitive cation channel 2, neuronal isoform b |sodium ion transport ; GO:0006814 |ion transport ; GO:0006811 REAB|This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) |superfamily. The members of this family are amiloride-sensitive sodium channels |that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, |and a large extracellular loop, which has many cysteine residues with conserved |spacing. The member encoded by this gene is expressed in most if not all brain neurons, |and it may be an ion channel subunit; however, its function as an ion channel remains |unknown. Alternative splicing of this gene generates 2 transcript products. CHR|12 PRD|hBNaC2 |Cation channel, amiloride-sensitive, neuronal, 2 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=274361 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=41[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:6944484 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_020039 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_020039 DBL|UNIGENE:Hs.274361 |OMIM:602866 |SNP:41 MAP|12q12 ENZ|ion channel activity ; GO:0005216 |amiloride-sensitive sodium channel activity ; GO:0015280 CEL|integral to membrane ; GO:0016021 HG|species == rat; score == 1068; expect == 0.0; MEOW:ref|NP_077068.1| (98%) |species == Human; gene == ACCN1; score == 716; expect == 0.0; MEOW:HUgn0000040 (66%) |species == Mouse; gene == Accn1; score == 601; expect == 2e-172; MEOW:MGgn0000050 (59%) |species == Mouse; gene == Accn4; score == 485; expect == 1e-137; MEOW:MGgn0042059 (49%) |species == Worm; gene == T28B8.5; score == 147; expect == 7.6e-36; MEOW:CEgn0017174 (23%) |species == Worm; gene == unc-8; score == 136; expect == 1.7e-32; MEOW:CEgn0002894 (27%) |species == Worm; gene == mec-10; score == 135; expect == 3.9e-32; MEOW:CEgn0001940 (27%) |species == Worm; gene == C24G7.4; score == 135; expect == 3.9e-32; MEOW:CEgn0005283 (26%) |species == Worm; gene == T28F4.2; score == 134; expect == 8.7e-32; MEOW:CEgn0017227 (23%) |species == Worm; gene == unc-105; score == 132; expect == 4.3e-31; MEOW:CEgn0002985 (27%) } # EOR GENR { RETE|ID 1 HUgn0000042 DID 1 LocusLink:42 NAM 1 acetylcholinesterase-associated protein ORG 1 Homo sapiens SYM 1 ACHAP ID|HUgn0000042 DID|LocusLink:42 ORG|Homo sapiens SYM|ACHAP NAM|acetylcholinesterase-associated protein URL|http://www.gdb.org/gdb-bin/genera/accno?GDB:9836107 } # EOR GENR { RETE|ID 1 HUgn0000043 CHR 1 7 DID 1 LocusLink:43 MAP 1 7q22 NAM 1 acetylcholinesterase (YT blood group) ORG 1 Homo sapiens SYM 1 ACHE ID|HUgn0000043 DID|LocusLink:43 ORG|Homo sapiens RSQ|REFSEQ:NM_000665 |REFSEQ:NM_015831 RPA|REFPROT:NP_000656 |REFPROT:NP_056646 DBA|XM:NM_000665 |XM:NM_015831 |XM:NM_000665 |XM:NM_015831 |NA:AF002993 |NA:L06484 |NA:L42812 |NA:AF334270 |NA:BC026315 |NA:BC036813 |NA:M55040 |NA:none PAC|XP:NP_000656 |XP:NP_056646 |XP:NP_000656 |XP:NP_056646 SYM|ACHE NAM|acetylcholinesterase (YT blood group) SYN|YT FNC|acetylcholinesterase PI-linked form precursor |acetylcholinesterase hydrophilic form precursor REAB|Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular |junctions and brain cholinergic synapses, and thus terminates signal transmission. |It is also found on the red blood cell membranes, where it constitutes the Yt blood |group antigen. Acetylcholinesterase exists in multiple molecular forms which possess |similar catalytic properties, but differ in their oligomeric assembly and mode of |cell attachment to the cell surface. It is encoded by the single ACHE gene, and |the structural diversity in the gene products arises from alternative mRNA splicing, |and post-translational associations of catalytic and structural subunits. The major |form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic |species, which forms disulfide-linked oligomers with collagenous, or lipid-containing |structural subunits. The other, alternatively spliced form, expressed primarily |in the erythroid tissues, differs at the C-terminal end, and contains a cleavable |hydrophobic peptide with a GPI-anchor site. It associates with the membranes through |the phosphoinositide (PI) moieties added post-translationally. CHR|7 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=154495 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=43[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:118746 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_015831 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_015831 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=154495 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=05010 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00561 |http://www.bioc.aecom.yu.edu/bgmut/yt.htm DBL|UNIGENE:Hs.154495 |OMIM:100740 |SNP:43 |UWCM:118746.html ENZ|EC:3.1.1.7 MAP|7q22 PHP|Blood group, Yt system HG|species == Mouse; gene == Ache; score == 1086; expect == 0.0; MEOW:MGgn0000055 (88%) |species == Zfish; gene == ache; score == 751; expect == 0.0; MEOW:ZFgn0002325 (59%) |species == rat; score == 647; expect == 0.0; MEOW:ref|NP_075231.1| (52%) |species == Human; gene == BCHE; score == 646; expect == 0.0; MEOW:HUgn0000590 (52%) |species == Mosquito; gene == LOC16929; score == 506; expect == 8e-144; MEOW:AGgn0016929 (47%) |species == Worm; gene == ace-1; score == 436; expect == 2e-122; MEOW:CEgn0000003 (41%) |species == Fruitfly; gene == Ace; score == 376; expect == 2e-104; MEOW:FBgn0000024 (35%) } # EOR GENR { RETE|ID 1 HUgn0000046 CHR 1 12 DID 1 LocusLink:46 MAP 1 12p13.3-p11.2 NAM 1 acrocallosal syndrome ORG 1 Homo sapiens SYM 1 ACLS ID|HUgn0000046 DID|LocusLink:46 ORG|Homo sapiens SYM|ACLS NAM|acrocallosal syndrome CHR|12 DBL|OMIM:200990 MAP|12p13.3-p11.2 URL|http://www.gdb.org/gdb-bin/genera/accno?GDB:136346 } # EOR GENR { RETE|ID 1 HUgn0000047 CHR 1 17 DID 1 LocusLink:47 MAP 1 17q12-q21 NAM 1 ATP citrate lyase ORG 1 Homo sapiens SYM 1 ACLY ID|HUgn0000047 DID|LocusLink:47 ORG|Homo sapiens RSQ|REFSEQ:NM_001096 RPA|REFPROT:NP_001087 DBA|XM:NM_001096 |NA:BC006195 |NA:U18197 |NA:X64330 |NA:none PAC|XP:NP_001087 SYM|ACLY NAM|ATP citrate lyase SYN|ATPCL |CLATP FNC|ATP citrate lyase |ATP catabolism ; GO:0006200 |coenzyme A metabolism ; GO:0015936 |citrate metabolism ; GO:0006101 |tricarboxylic acid cycle ; GO:0006099 |metabolism ; GO:0008152 |lipid biosynthesis ; GO:0008610 REAB|ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic |acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight |approximately 440,000) of apparently identical subunits. It catalyzes the formation |of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis |of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic |pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase |may be involved in the biosynthesis of acetylcholine. CHR|17 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=387567 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=47[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:316220 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_001096 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001096 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=387567 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00020 DBL|UNIGENE:Hs.387567 |OMIM:108728 |SNP:47 ENZ|EC:4.1.3.8 |citrate (Si)-synthase activity ; GO:0004108 |ATP citrate synthase activity ; GO:0003878 |ATP binding ; GO:0005524 |magnesium ion binding ; GO:0000287 |transferase activity ; GO:0016740 MAP|17q12-q21 CEL|citrate lyase complex ; GO:0009346 HG|species == rat; score == 2086; expect == 0.0; MEOW:ref|NP_058683.1| (95%) |species == Mouse; gene == Acly; score == 2046; expect == 0.0; MEOW:MGgn0000059 (93%) |species == Fruitfly; gene == ATPCL; score == 1489; expect == 0.0; MEOW:FBgn0020236 (67%) |species == Mosquito; gene == LOC12364; score == 1474; expect == 0.0; MEOW:AGgn0012364 (67%) |species == Worm; gene == D1005.1; score == 1283; expect == 0.0; MEOW:CEgn0007269 (58%) |species == Worm; gene == B0365.1; score == 1279; expect == 0.0; MEOW:CEgn0003427 (59%) |species == Weed; gene == At3g06650; score == 647; expect == 0.0; MEOW:ATgn0016816 (51%) |species == Weed; gene == At5g49460; score == 642; expect == 0.0; MEOW:ATgn0022823 (51%) |species == rice; score == 626; expect == 5e-179; MEOW:gnl|TIGR|8350.m01804 (53%) } # EOR GENR { RETE|ID 1 HUgn0000048 CHR 1 9 DID 1 LocusLink:48 MAP 1 9p22-q32 NAM 1 aconitase 1, soluble ORG 1 Homo sapiens SYM 1 ACO1 ID|HUgn0000048 DID|LocusLink:48 ORG|Homo sapiens RSQ|REFSEQ:NM_002197 RPA|REFPROT:NP_002188 DBA|XM:NM_002197 |NA:AF261088 |NA:AK057904 |NA:BC018103 |NA:M58510 |NA:Z11559 |NA:none PAC|XP:NP_002188 SYM|ACO1 NAM|aconitase 1, soluble SYN|IRP1 |IREB1 |IREBP FNC|aconitase 1 |tricarboxylic acid cycle ; GO:0006099 |metabolism ; GO:0008152 |negative regulation of translation ; GO:0016478 REAB|Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is |a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop |structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin |receptor mRNA. The iron-induced binding to the IRE results in repression of translation |of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading |transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. | It was also shown to have aconitase activity, and hence grouped with the aconitase |family of enzymes. CHR|9 PRD|Aconitase, soluble |iron-responsive element binding protein 1 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=319677 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=48[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:118960 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_002197 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_002197 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=319677 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00020 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00630 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00720 DBL|UNIGENE:Hs.319677 |OMIM:100880 |SNP:48 ENZ|EC:4.2.1.3 |aconitate hydratase activity ; GO:0003994 |RNA binding ; GO:0003723 |lyase activity ; GO:0016829 MAP|9p22-q32 CEL|cytoplasm ; GO:0005737 HG|species == Mouse; gene == Aco1; score == 1622; expect == 0.0; MEOW:MGgn0000060 (93%) |species == rat; score == 1602; expect == 0.0; MEOW:ref|XP_346736.1| (93%) |species == Mosquito; score == 1204; expect == 0.0; MEOW:AGgn0015921 (67%) |species == Fruitfly; gene == Irp-1B; score == 1171; expect == 0.0; MEOW:FBgn0024957 (67%) |species == Fruitfly; gene == Irp-1A; score == 1161; expect == 0.0; MEOW:FBgn0024958 (67%) |species == Weed; gene == At2g05710; score == 1090; expect == 0.0; MEOW:ATgn0009667 (62%) |species == rice; score == 1080; expect == 0.0; MEOW:gnl|TIGR|8356.m00870 (61%) |species == Weed; gene == At4g35830; score == 1077; expect == 0.0; MEOW:ATgn0017137 (60%) |species == rice; score == 1059; expect == 0.0; MEOW:gnl|TIGR|8360.m00338 (60%) |species == Weed; gene == At4g26970; score == 1050; expect == 0.0; MEOW:ATgn0018182 (60%) |species == Human; gene == IREB2; score == 981; expect == 0.0; MEOW:HUgn0003658 (53%) |species == ecoli; score == 863; expect == 0.0; MEOW:ref|NP_415792.1| (52%) } # EOR GENR { RETE|ID 1 HUgn0000049 CHR 1 22 DID 1 LocusLink:49 MAP 1 22q13-qter NAM 1 acrosin ORG 1 Homo sapiens SYM 1 ACR ID|HUgn0000049 DID|LocusLink:49 ORG|Homo sapiens RSQ|REFSEQ:NM_001097 RPA|REFPROT:NP_001088 DBA|XM:NM_001097 |NA:M77379 |NA:M77381 |NA:X54017 |NA:X66188 |NA:Y00970 |NA:none PAC|XP:NP_001088 SYM|ACR NAM|acrosin FNC|acrosin precursor |acrosome reaction ; GO:0007340 |proteolysis and peptidolysis ; GO:0006508 REAB|Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It |is a typical serine proteinase with trypsin-like specificity. It is stored in the |acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis |of the zona pellucida, thus facilitating penetration of the sperm through the innermost |glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in |the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in |the haploid spermatids. CHR|22 PRD|proacrosin URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=183088 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=49[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:119645 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_001097 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001097 DBL|UNIGENE:Hs.183088 |OMIM:102480 |SNP:49 ENZ|EC:3.4.21.10 |trypsin activity ; GO:0004295 |acrosin activity ; GO:0004284 |chymotrypsin activity ; GO:0004263 |hydrolase activity ; GO:0016787 MAP|22q13-qter HG|species == Mouse; gene == Acr; score == 501; expect == 3e-142; MEOW:MGgn0000066 (68%) |species == rat; score == 451; expect == 3e-127; MEOW:ref|NP_036622.1| (63%) |species == Human; gene == bA395L14.13; score == 250; expect == 4.9e-67; MEOW:HUgn0284967 (96%) |species == Mosquito; gene == LOC17112; score == 161; expect == 3.1e-40; MEOW:AGgn0017112 (35%) |species == Fruitfly; gene == Sb; score == 161; expect == 4.3e-40; MEOW:FBgn0003319 (36%) |species == Mosquito; gene == LOC22018; score == 155; expect == 2.2e-38; MEOW:AGgn0022018 (35%) |species == Fruitfly; gene == CG10663; score == 149; expect == 2.2e-36; MEOW:FBgn0036287 (31%) |species == Mosquito; gene == LOC11642; score == 148; expect == 2.4e-36; MEOW:AGgn0011642 (37%) |species == Fruitfly; gene == CG11824; score == 147; expect == 8.3e-36; MEOW:FBgn0033360 (34%) |species == Fruitfly; gene == CG4914; score == 147; expect == 4.9e-36; MEOW:FBgn0036436 (36%) |species == Mosquito; gene == LOC4000; score == 146; expect == 1.0e-35; MEOW:AGgn0004000 (38%) |species == Mosquito; gene == LOC12218; score == 146; expect == 1.4e-35; MEOW:AGgn0012218 (37%) |species == Worm; gene == C07G1.1; score == 145; expect == 3.7e-35; MEOW:CEgn0004322 (36%) |species == Fruitfly; gene == CG9372; score == 145; expect == 3.2e-35; MEOW:FBgn0036891 (35%) |species == Mosquito; gene == LOC17160; score == 144; expect == 5.2e-35; MEOW:AGgn0017160 (35%) |species == Mosquito; score == 142; expect == 2.6e-34; MEOW:AGgn0028900 (33%) |species == Fruitfly; gene == CG18735; score == 142; expect == 1.6e-34; MEOW:FBgn0042098 (34%) |species == Mosquito; gene == LOC12216; score == 141; expect == 4.4e-34; MEOW:AGgn0012216 (35%) |species == Fruitfly; gene == CG2105; score == 140; expect == 7.8e-34; MEOW:FBgn0033192 (34%) |species == Fruitfly; gene == CG8213; score == 138; expect == 3.0e-33; MEOW:FBgn0033359 (34%) |species == Mosquito; gene == LOC10961; score == 137; expect == 6.3e-33; MEOW:AGgn0010961 (33%) |species == Fruitfly; gene == CG8172; score == 136; expect == 1.5e-32; MEOW:FBgn0033362 (33%) |species == Mosquito; score == 135; expect == 2.4e-32; MEOW:AGgn0025376 (32%) |species == Fruitfly; gene == CG4386; score == 135; expect == 3.3e-32; MEOW:FBgn0034661 (32%) |species == Mosquito; score == 134; expect == 5.8e-32; MEOW:AGgn0026298 (38%) |species == Worm; gene == ZK546.15; score == 134; expect == 5.0e-32; MEOW:CEgn0021019 (32%) |species == Mosquito; gene == LOC19999; score == 132; expect == 1.5e-31; MEOW:AGgn0019999 (37%) |species == Mosquito; gene == LOC15292; score == 131; expect == 5.4e-31; MEOW:AGgn0015292 (36%) |species == chimp; score == 126; expect == 4.8e-31; MEOW:sp|Q95ND7|Q95ND7 (35%) } # EOR GENR { RETE|ID 1 HUgn0000050 CHR 1 22 DID 1 LocusLink:50 MAP 1 22q11.2-q13.31 NAM 1 aconitase 2, mitochondrial ORG 1 Homo sapiens SYM 1 ACO2 ID|HUgn0000050 DID|LocusLink:50 ORG|Homo sapiens RSQ|REFSEQ:NM_001098 RPA|REFPROT:NP_001089 DBA|XM:NM_001098 |NA:U87926 |NA:U87927 |NA:U87928 |NA:U87929 |NA:U87930 |NA:U87931 |NA:U87932 |NA:U87933 |NA:U87934 |NA:U87935 |NA:U87936 |NA:U87937 |NA:U87938 |NA:U87939 |NA:BC014092 |NA:BC026196 |NA:U80040 |NA:none PAC|XP:NP_001089 SYM|ACO2 NAM|aconitase 2, mitochondrial FNC|aconitase 2 |citrate metabolism ; GO:0006101 |tricarboxylic acid cycle ; GO:0006099 |energy pathways ; GO:0006091 REAB|Aconitase 2 is an enzyme of the TCA cycle and is encoded in the nucleus and active |within the mitochondrion. Aconitase catalyzes the interconversion of citrate to |isocitrate via cis-aconitate in the second step of the TCA cycle. Isoforms of ACO2 |have been reported but are not well characterized. CHR|22 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=300463 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=50[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:118961 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_001098 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001098 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=300463 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00020 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00630 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00720 DBL|UNIGENE:Hs.300463 |OMIM:100850 |SNP:50 ENZ|EC:4.2.1.3 |aconitate hydratase activity ; GO:0003994 |iron ion binding ; GO:0005506 |lyase activity ; GO:0016829 MAP|22q11.2-q13.31 CEL|mitochondrion ; GO:0005739 HG|species == Mouse; gene == Aco2; score == 1518; expect == 0.0; MEOW:MGgn0000061 (96%) |species == rat; score == 1505; expect == 0.0; MEOW:ref|NP_077374.1| (95%) |species == Human; gene == LOC343508; score == 1296; expect == 0.0; MEOW:HUgn0343508 (85%) |species == Mosquito; score == 1147; expect == 0.0; MEOW:AGgn0018525 (74%) |species == Worm; gene == aco-2; score == 1129; expect == 0.0; MEOW:CEgn0037206 (75%) |species == Fruitfly; gene == CG4706; score == 1074; expect == 0.0; MEOW:FBgn0037862 (70%) |species == Yeast; gene == ACO1; score == 1026; expect == 0.0; MEOW:SGgn0004295 (67%) |species == Weed; gene == At4g26970; score == 204; expect == 1.6e-52; MEOW:ATgn0018182 (28%) |species == rice; score == 200; expect == 6.5e-51; MEOW:gnl|TIGR|8356.m00870 (27%) |species == Weed; gene == At2g05710; score == 195; expect == 7.3e-50; MEOW:ATgn0009667 (27%) |species == ecoli; score == 188; expect == 1.0e-48; MEOW:ref|NP_415792.1| (27%) |species == ecoli; score == 160; expect == 3.3e-39; MEOW:ref|NP_415292.1| (24%) } # EOR GENR { RETE|ID 1 HUgn0000051 CHR 1 17 DID 1 LocusLink:51 MAP 1 17q24-q25 NAM 1 acyl-Coenzyme A oxidase 1, palmitoyl ORG 1 Homo sapiens SYM 1 ACOX1 ID|HUgn0000051 DID|LocusLink:51 ORG|Homo sapiens RSQ|REFSEQ:NM_004035 |REFSEQ:NM_007292 RPA|REFPROT:NP_004026 |REFPROT:NP_009223 DBA|XM:NM_004035 |XM:NM_007292 |NA:U03254 |NA:U03268 |NA:BC008767 |NA:BC010425 |NA:BX537380 |NA:S69189 |NA:U07866 |NA:X71440 |NA:none PAC|XP:NP_004026 |XP:NP_009223 SYM|ACOX1 NAM|acyl-Coenzyme A oxidase 1, palmitoyl SYN|ACOX |MGC1198 |PALMCOX FNC|acyl-Coenzyme A oxidase isoform a |acyl-Coenzyme A oxidase isoform b |fatty acid beta-oxidation ; GO:0006635 |electron transport ; GO:0006118 |prostaglandin metabolism ; GO:0006693 |energy pathways ; GO:0006091 REAB|The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation |pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. ACOX1 |donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. |Defects in the ACOX1 gene result in pseudoneonatal adrenoleukodystrophy, a disease |that is characterized by accumulation of very long chain fatty acids. CHR|17 PRD|acyl-coenzyme A oxidase 1 URL|http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=379991 |http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=51[loc]&TAXID=9606 |http://www.gdb.org/gdb-bin/genera/accno?GDB:282672 |http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_007292 |http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_007292 |http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=379991 |http://www.geneclinics.org/query?mim=264470 |http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=00071 DBL|UNIGENE:Hs.379991 |OMIM:264470 |SNP:51 ENZ|EC:1.3.3.6 |acyl-CoA oxidase activity ; GO:0003997 |electron donor activity ; GO:0009053 |oxidoreductase activity ; GO:0016491 MAP|17q24-q25 PHP|Adrenoleukodystrophy, pseudoneonatal CEL|peroxisome ; GO:0005777 HG|species == rat; score == 1147; expect == 0.0; MEOW:ref|NP_059036.1| (85%) |species == Mouse; gene == Acox1; score == 1132; expect == 0.0; MEOW:MGgn0000062 (84%) |species == Human; gene == ACOX2; score == 545; expect == 2e-155; MEOW:HUgn0008309 (44%) |species == Mosquito; score == 542; expect == 2e-154; MEOW:AGgn0020032 (43%) |species == Weed; gene == At2g35690; score == 532; expect == 3e-151; MEOW:ATgn0007600 (43%) |species == Weed; gene == At4g16760; score == 532; expect == 3e-151; MEOW:ATgn0017917 (44%) |species == Fruitfly; gene == CG5009; score == 528; expect == 2e-150; MEOW:FBgn0027572 (43%) |species == rice; score == 524; expect == 1e-148; MEOW:gnl|TIGR|8354.m00035 (43%) |species == Mosquito; score == 516; expect == 7e-147; MEOW:AGgn0020118 (41%) |species == Worm; gene == F08A8.1; score == 513; expect == 1e-145; MEOW:CEgn0007842 (43%) |species == Worm; gene == F59F4.1; score == 504; expect == 4e-143; MEOW:CEgn0012572 (42%) |species == Worm; gene == F08A8.4; score == 493; expect == 1e-139; MEOW:CEgn0007845 (42%) |species == Worm; gene == F08A8.3; score == 491; expect == 5e-139; MEOW:CEgn0007844 (42%) |species == Worm; gene == F08A8.2; score == 475; expect == 2e-134; MEOW:CEgn0007843 (40%) |species