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.. Preferences
Help
.. Preferences
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| Molecular function | protein carrier activity, serine protease inhibitor activity, wide-spectrum protease inhibitor activity |
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| Biological process | alpha 2 macroglobulin precursor, intracellular protein transport |
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| Cellular component | -- | ||
| Protein domains | -- | ||
| Chromosome Map location |
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| Ref. sequence Ref. protein |
REFSEQ:NM_000014 REFPROT:NP_000005 |
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| Similar genes | Fruitfly TepII FBgn0041182 (28%) Human PZP HUgn0005858 (72%) Mosquito LOC19522 AGgn0019522 (33%) Mouse A2m MGgn0041598 (71%); Mug1 MGgn0008069 (58%) Worm ZK337.1a CEgn0020893 (28%); ZK337.1b CEgn0020894 (28%); ZK337.1c CEgn0034425 (27%) rat -- ref |NP_036620.1| (73%) ref |XP_346725.1| (59%) |
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| Synonyms | -- | ||
| Database ID Ref. Database |
HUgn0000002 LocusLink:2 |
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| Database accessions | UNIGENE:Hs.74561, OMIM:103950, SNP:2, UWCM:119639.html | ||
| Summary | Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits, many proteases, including trypsin, thrombin and collagenase. A2M is implicated in, Alzheimer disease (AD) due to its ability to mediate the clearance and degradation, of A-beta, the major component of beta-amyloid deposits. |
| Database URL | http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=74561, http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=2[loc]&TAXID=9606, http://www.gdb.org/gdb-bin/genera/accno?GDB:119639, http://www.ensembl.org/Homo_sapiens/contigview?geneid=NM_000014, http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_000014, http://mgc.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=74561, http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=hsa&mapno=05010 |
Phenotypic info. | Alzheimer disease, susceptibility to Emphysema due to alpha-2-macroglobulin deficiency |