>From bronze!sol.ctr.columbia.edu!spool.mu.edu!uwm.edu!bionet!EMBL-HEIDELBERG.DE!Des.Higgins Thu Sep 5 07:51:03 EST 1991 Article: 1286 of bionet.software Path: bronze!sol.ctr.columbia.edu!spool.mu.edu!uwm.edu!bionet!EMBL-HEIDELBERG.DE!Des.Higgins >From: Des.Higgins@EMBL-HEIDELBERG.DE (Des Higgins) Newsgroups: bionet.software Subject: Clustal V: new version of Clustal available. Message-ID: Date: 5 Sep 91 09:09:00 GMT Article-I.D.: EMBL-Hei.F1150630A040C719 Sender: news@genbank.bio.net Distribution: bionet Lines: 49 Clustal V: software for multiple sequence alignment now available from the EMBL file server. The CLUSTAL package of programs for multiple sequence alignment has been completely rewritten in C and is now available from the EMBL file server. The package quickly and flexibly aligns large numbers of nucleic acid or protein sequences. It is completely menu driven and on-line help is provided. Many new features have been added including: - improved sequence input (automatically detect and read NBRF/PIR, FASTA and EMBL/SWISSPROT formats); - a choice of 4 output formats (old Clustal, GCG .msf, NBRF/PIR and Phylip); - phylogenetic trees after alignment using the Neighbor-Joining method of Saitou and Nei with a bootstrap option to calculate confidence intervals; - the ability to align old alignments with each other; - a full command line interface; - improved portability; with 1 change to 1 header file, the code will compile and run on the following systems: IBM PC (Turbo C); VAX/VMS C; Apple Mac (Think C); Decstation (Ultrix C) and Sun (Gnu C, but not the native Sun C). To get the package, send a mail message with the following words: "help" and "help software" on 2 lines with no quotes to the address: Netserv@EMBL-Heidelberg.DE If you have any queries regarding the package, please mail Des Higgins at the address: Higgins@EMBL-Heidelberg.DE Des Higgins and Rainer Fuchs EMBL Data Library, Heidelberg, Germany. Alan Bleasby Daresbury, UK.