Since 1993, Genethon and the CEPH-Fondation-Jean-Dausset with the support of the RESIG project (Networks of computer servers for Genomes) and a grant from the GREG (Groupement pour la Recherche et l'Etude des Genomes) have been collecting a software directory of general interest in molecular biology and genetics, and distributing it on the Internet. In the long run, such a directory ought to contain most of the existing programmes (from academic, processing servers to commercial programmes), with some emphasis on network-oriented multi-user environments (eg UNIX, VAX/VMS). The EBI (European Bioinformatics Institute - an EMBL outstation) has decided to support this initiative by taking care of the making of the catalog - as a collaborative project - and its distribution. We would like to thank the computing group of Genethon and Dominique Caterina from CEPH, instigators of this project, for their contribution. This directory cannot be up-to-date without the help of the biocomputing community, that is to say the programme authors, archive adminsitrators and end-users. Thus, any corrections, comments and announcements of new software would be mostly welcome at the following addresses : Email: Patricia.Rodriguez-Tome@ebi.ac.uk Web page (preferred but it will work only if your browser support forms) : http://www.ebi.ac.uk/biocat/biocat_form.html for new entries, and http://www.ebi.ac.uk/biocat/biocatcorr_form.html for corrections. Smail: Dr. Patricia Rodriguez-Tome EMBL Oustattion, Hinxton - The European Bioinformatics Institute Hinxton Hall, Hinxton Cambridge CB10 1RQ UK Subsequently, other areas will be taken into account, but where does molecular biology stop ?